corticotropin-releasing hormone

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corticotropin-releasing hormone

[‚kȯrd·ə·kō′trō·pən ri¦lēs·iŋ ‚hȯr‚mōn]
(biochemistry)
A substance produced by the hypothalamus that stimulates the pituitary gland to produce adrenocorticotropic hormone (ACTH). Abbreviated CRH.
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The stress hormone, corticotrophin-releasing factor (CRF), was found to be raised threefold in both single stress models, albeit the effect of NMS was not statistically significant (p = 0.
Antagonism of corticotrophin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence.
Neuroanotomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: implications for balancing stress and affect.
Human umbilical vein endothelial cells: a new source and potential target for corticotrophin-releasing factor.
Early post-natal experience alters hypothalamic corticotrophin-releasing factor mRNA, median eminence CRF content and stress induced release in adults.
Nasdaq:NBIX) Thursday announced that its scientists presented data which further validates corticotrophin-releasing factor (CRF) for anxiety/depression at the Society for Neuroscience meeting held this week in New Orleans.
b) Treatment with STW5 protected against the rise in plasma levels of corticotrophin-releasing factor and corticosterone
Among the locus coeruleus's many functions is the responsibility for mediating many of the sympathetic effects during stress, suppression of the parasympathetic system as needed, and activation of the corticotrophin-releasing factor from the hypothalamus.
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotrophin-releasing factor.
Pipeline candidates fall under major therapeutic classes such as serotonin receptor binders, adrenergic receptor anatagonist, corticotrophin-releasing factor antagonist, glutamate receptor modulator, GABA agonist, GABA receptor modulators, monoamine uptake inhibitor, mGluR agonist and vasopressin receptor antagonist and others.
Corticotrophin-releasing factor (CRF): A hormone produced in response to stress that helps mediate the stress response; is produced mainly in the hypothalamus but also can be produced in other brain regions.