Editor's Note: "We found 30-day mortality from stroke increased by around 20% if patients were taking a COX-2 inhibitor
before admission," said study co-author Christian Christiansen, PhD, of Aarhus University Hospital.
In 2000, Celebrex (celecoxib), the leading COX-2 inhibitor
, had sales of approximately $2.
For this study, we were interested only in those recipients who were continuously taking either a COX-2 inhibitor
, an NSAID, or other pain relieves throughout the 2-year study period.
However, COX-2 inhibitors
have been linked to a heightened risk of heart problems (SN: 10/30/04, p.
We believe that some physicians have been prescribing the new COX-2 inhibitors
as the first line of treatment.
The latest study showed that, as expected, COX-2 inhibitors
doubled the risk of an attack - but so did the two non-steroidal anti-inflammatories.
The risk of giving a COX-2 inhibitor
that has been most widely discussed over the last several years would be the cardiovascular risk.
Among them were 27, 000 patients who had been taking Vioxx, which belongs to a family of drugs known as Cox-2 inhibitors
Bextra (valdecoxib), its second COX-2 inhibitor
, for use in osteoarthritis and
A second Yale study revealed the safety and effectiveness of a COX-2 inhibitor
, rofecoxib, as a surgical pain reliever.
A recent study published in the Annals of Internal Medicine (2000, 133) compared the effects of the older COX-1/COX-2 inhibitors
with the newer COX-2 inhibitor
Additionally, the millions of patients taking over-the-counter NSAIDs could end up with a prescription cox-2 inhibitor