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cox-2 inhibitor
(redirected from Coxib)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
cox-2 inhibitor: see nonsteroidal anti-inflammatory drug nonsteroidal anti-inflammatory drug, a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID .
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Though this coxib-specific "prothrombotic mechanism" is still being investigated, the theory goes that by inhibiting the COX-2 enzymes that dilate blood vessels, while allowing the production of the COX-1 enzymes that cause blood platelets to stick, coxibs can create a friendly environment for the formation of dangerous blood clots in some people.
In fact, while other agents have been shown to raise blood pressure between 4 and 6% in hypertensives, one coxib in particular appears to raise it by some 25 to 30%.
27: Leading coxib brands in the global autoimmune market, 2006-07 94 Table 3.
 
 
 
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