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cox-2 inhibitor |
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cox-2 inhibitor: see nonsteroidal anti-inflammatory drug nonsteroidal anti-inflammatory drug, a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID ..... Click the link for more information. . How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Though this coxib-specific "prothrombotic mechanism" is still being investigated, the theory goes that by inhibiting the COX-2 enzymes that dilate blood vessels, while allowing the production of the COX-1 enzymes that cause blood platelets to stick, coxibs can create a friendly environment for the formation of dangerous blood clots in some people. In fact, while other agents have been shown to raise blood pressure between 4 and 6% in hypertensives, one coxib in particular appears to raise it by some 25 to 30%. Also included in other promoted medicines were global sales of Merck's coxib, ARCOXIA, which reached $57 million in the first quarter, compared with $30 million in the first quarter of 2004. |
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