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cox-2 inhibitor
(redirected from Coxibs)

   Also found in: Medical, Wikipedia 0.03 sec.
cox-2 inhibitor: see nonsteroidal anti-inflammatory drug nonsteroidal anti-inflammatory drug, a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID
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Arthritis medicines and cardiovascular events: "house of coxibs.
Though this coxib-specific "prothrombotic mechanism" is still being investigated, the theory goes that by inhibiting the COX-2 enzymes that dilate blood vessels, while allowing the production of the COX-1 enzymes that cause blood platelets to stick, coxibs can create a friendly environment for the formation of dangerous blood clots in some people.
The potentially harmful effects of NSAIDs and coxibs due to a rise in arterial blood pressure are increasingly acknowledged.
 
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