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C4H9O2N3α-Methylguanidine-acetic acid; a compound present in vertebrate muscle tissue, principally as phosphocreatine.



N-methylguanidoacetic acid. Molecular weight, 131.14; melting point, 315°C (with dissociation):

Creatine is soluble in hot water, slightly soluble in alcohol, and insoluble in ether. The interaction of mineral acids and creatine produces the lactam creatinine. This reaction is the basis of one of the methods used to determine creatine content. Creatine dissociates into urea and methylglycine in an alkaline medium.

Creatine was discovered in 1835 by the French scientist M. Chevreul in extracts from skeletal muscles. It is found in the muscle tissue of all vertebrates (approximately 0.5 percent of the muscle weight) in the form of the unstable creatinephosphoric acid, which takes part in supplying the energy required for muscle contraction. Smaller quantities are present in nerve tissue, blood, liver, and kidneys. Creatine biosynthesis in an organism is achieved in the kidneys from the amino acids glycine and arginine, forming glycocyamine. The glycocyamine undergoes subsequent methylation in the liver in the presence of the amino acid methionine to yield creatine.


References in periodicals archive ?
The report also provides information about the uses, dosage, and potential side effects of creatine and BCAAs and explains differences among forms of these ingredients, such as creatine monohydrate, creatine AKG, dicreatine malate, and KreAlkalyn.
Although creatine monohydrate is clearly safe for healthy people with a very low side-effects profile using up to 10 grams per day, are there specific groups who should not use it?
But just what is Creatine Monohydrate Powder and what are the benefits of it being 'micronized'?
17) The protocol for loading creatine in this study was four to six doses of 5 g of creatine monohydrate per day for five days to saturate muscle creatine stores and increase concentrations by 20%.
Creatine monohydrate is one of the most commonly ingested and researched sports supplements today and is a popular aspect of sports nutrition and ergogenic aids.
Due to its abundant resources and super competitive pricing, China has all but cornered the market for many ingredients, including ascorbic acid, chondroitin, glucosamine sulfates, B vitamins, creatine monohydrate and many others.
Creatine Monohydrate is naturally produced by the body and is stored in muscles and in the bloodstream.
The affect of oral creatine monohydrate supplementation on running velocity.
How Participants Learned of Creatine Monohydrate Use Athletes Knowledge Source Male Female Percentage Friend 273 58 43.
Featured supplements include PROLAB([R]) Creatine Monohydrate in great-tasting, new and upcoming flavors, as well as PROLAB([R]) Pure Whey.
Creatine Monohydrate The ISSN has called creatine "the most effective nutritional available to athletes to increase high intensity exercise capacity and muscle mass during training.