Key words: asbestos, chrysotile, crocidolite
, meta-analysis, ovarian cancer, SMR.
CONCLUSIONS: Oxidative DNA damage repaired by XRCC1 (oxidized bases, single-strand breaks) is a major cause of chromosomal breaks induced by crocidolite
and Libby amphibole.
1989 Switzerland bans crocidolite
, amosite, and chrysotile (with exceptions).
The principal varieties of asbestos are a serpentine material called chrysotile, and crocidolite
, amosite, anthophyllite, tremolite, and actinolite--which are a type of dark mineral called amphiboles (Mirabelli et al.
Evaluation of the Fate and Pathological Response in the Lung and Pleura of Brake Dust Alone and in Combination with Added Chrysotile Compared to Crocidolite
Asbestos Following Short-Term Inhalation Exposure," Toxicol.
There are three commercial types, listed in the order of most deadly, crocidolite
, amosite and chrysotile.
There is a ban on crocidolite
or blue asbestos and amosite or brown asbestos while the use of chrysolite or white asbestos is not banned and permitted in high density products as fire proofing, clothing, roofing felts or related products, asbestos cement roofing and flat sheet, friction materials, high temperature textile products etc.
DISCUSSION: Malignant mesothelioma is pleural malignancy strongly associated with exposure to crocidolite
, chrysotile, amosite and all other type of asbestos.
Adopted in January 2000, the CCO strictly prohibits the use of amosite (brown) and crocidolite
(blue) asbestos fibers and of products containing these fibers, but permits the use of chrysolite (white) asbestos fibers in high density products.
Malignant pleural and peritoneal mesotheliomas in former miners and millers of crocidolite
at Wittenoom, Western Australia.
It appears that while crocidolite
is a powerful cause of both lung cancer and mesothelioma, the cancer burden from chrysotile tilts much more towards lung cancer than mesothelioma.
Among Asbestos (primarily the crocidolite
variety) is considered the main risk factor.