cryoglobulin

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Related to Cryoglobulins: cryoglobulinemia

cryoglobulin

[¦krī·ō′gläb·yə·lən]
(pathology)
An abnormal protein, usually an immunoglobulin, which precipitates from plasma between 40 and 70°F (4.4 and 21°C).
References in periodicals archive ?
Hepatitis serologies, serum cryoglobulins, an HIV screen, and a hypercoagulable workup were negative.
The most common of these are preanalytic and analytic cryoglobulin precipitates.
64-66) Cryoglobulins have been classified into 3 categories by Brouet et al (67): type I, monoclonal, isolated, and often essential; type II, monoclonal, generally IgM with anti-polyclonal immunoglobulin activity (mostly IgG); and type III, polyclonal with more than one isotype.
If a properly collected blood is obtained, however, and the serum is separated at 37[degrees]C, then leaving the serum sample in a 37[degrees]C water overnight probably should not interfere with the laboratory testing for cryoglobulins.
An association with cryoglobulins in the patients' serum, nonspecific renal diseases, and unclassified systemic connective tissue diseases has been shown to relate this entity to an abnormal immunological response (7).
In class IV as well as in other classes of LGN, a variety of ultrastructural features may be observed, including focal or diffuse organized deposits (admixed with granular type), such as (1) crystalline/fingerprint-like structures in 5% to 10% of cases, usually with a thickness of 10 to 15 nm of the thin curvilinear bands and having cross-striations with a periodicity (Figure 7, A)37; and (2) cryoglobulins composed of larger hollow tubular-type deposits measuring 50 to 100 nm in thickness and occasional Congo red-negative fibrillary deposits, occurring at random or in parallel bundles, composed of polyclonal immunoglobulins (Figure 7, B).
Blood serologic tests indicated an erythrocyte sedimentation rate (ESR) of 62 mm/h and positive antinuclear antibodies (ANA) at a titer of 640 (homogeneous) but negative cryoglobulins, lupus anticoagulant, antineutrophil cytoplasmic antibodies (c-ANCA), and cardiolipin antibodies.
A few things to consider: RBC results and MCV may be falsely elevated due to the WBCs being counted simultaneously with RBCs and platelets; a spun hematocrit is approximately 2% to 5% higher than a calculated hematocrit; Hemoglobin may be falsely elevated due to turbidity; MCH and MCHC values may be inaccurate due to the affected parameters from which they're calculated; falsely elevated WBC values may be seen in samples with cryofibrinogen, cryoglobulins, nucleated red blood cells, micromegakaryocytes, or any particle sized in the range that is counting WBCs.
Crystalcryoglobulins, a subtype of cryoglobulins (immunoglobulins), form crystals in serum at temperatures below 37 [degrees]C (1, 2).
My laboratory was for immunoelectrophoresis, and we also tested serum for cryoglobulins and for viscosity (Figure 14).
For example, fibrin degradation products can cause falsely elevated fibrinogen antigen values when using sulphite precipitation, (35) thrombin clotting, (35) and some immunologic methods, (33) Falsely decreased fibrinogen antigen values can occur with the heat precipitation method in the presence of fibrin degradation products, (33) cryoglobulins, (34) and high plasma viscosity.