cryoglobulin

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Related to Cryoglobulins: cryoglobulinemia

cryoglobulin

[¦krī·ō′gläb·yə·lən]
(pathology)
An abnormal protein, usually an immunoglobulin, which precipitates from plasma between 40 and 70°F (4.4 and 21°C).
References in periodicals archive ?
The cryoglobulin count in her blood steadily decreased, and by April of this year it was undetectable.
This patient's recent weight loss was concerning for underlying systemic disease, so a laboratory work-up including complete blood count, serum protein electrophoresis, cold agglutinins, antinuclear antibody, rheumatoid factor, and cryoglobulins was performed.
Cryoglobulins are immunoglobulins that undergo reversible precipitation at low temperatures.
Further tests to assist with the diagnosis include antinuclear antibody profile, antineutrophil cytoplasmic antibody, C-reactive protein, cryoglobulins, serum complement, hepatitis B and C profile, HIV, venereal disease research laboratory test and uric acid levels.
Anticardiolipin auto antibodies in serum samples and cryoglobulins of patients with chronic hepatitis C infection.
In addition, M-proteins, especially those that are also cryoglobulins, can precipitate and cause erroneous measurements via several methods (1).
Studies for c-ANCA, anti-proteinase 3 (PR3), anti-GBM, cryoglobulins, complement levels, anti-nuclear antibody, rheumatoid factor, hepatitis A, B, and C, and creatinine kinase were normal.
Such patients have multiple serological abnormalities like anticardiolipin antibodies, cryoglobulins, and hypocomplementemia.
l) Cryoglobulinemia is a condition in which the blood contains large amounts of cryoglobulins which are proteins that become insoluble at reduced temperatures.
High circulating levels of cryoglobulins can arise in the setting of hepatitis C infection, but can also be seen in a number of autoimmune disorders and other infectious diseases.
A series of serum laboratory assessments were obtained including; a CBC with peripheral smear, cryoglobulins, cryofibrinogens, C-reactive protein (CRP), protein S activity and antigen, anti-neutrophil cytoplasmic antibodies, lupus anticoagulant, activated protein C (APC) resistance assay, prothrombin gene mutation assay, factor V Leiden assay, factor VIII activity level and a D-dimer assay.