Curtius rearrangement definition of Curtius rearrangement in the Free Online Encyclopedia.

Curtius reaction [′kərd·ē·əs rē‚ak·shən]

(organic chemistry)

A laboratory method for degrading a carboxylic acid to a primary amine by converting the acid to an acyl azide to give products which can be hydrolyzed to amines.

Curtius Reaction

a method of preparing primary amines from the azides of carboxylic acids:

Upon heating, the azide (I) decomposes with the formation of an intermediate particle—nitrene, or azine (II). The subsequent migration of the hydrocarbon radical R toward the nitrogen atom (Curtius rearrangement) yields an isocyanate (III). Isocyanates can be isolated during azide decomposition in inert solvents. Amine (V) is obtained as a result of the hydration of isocyanate and subsequent decarboxylation of the obtained carbamic acid (IV). The mechanism involved in the Curtius reaction is similar to the mechanism observed in the Hofmann and Lossen reactions. The Curtius reaction is used in laboratory organic synthesis. The German chemist T. Curtius first discovered the reaction in 1894.

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No references found			Curtice, Harlowe H. curtilage Curtin Curtin, John Curtin, John Joseph Curtin, Philip Curtis Cup Curtis Institute of Music Curtis, Benjamin R. Curtis, Benjamin Robbins Curtis, Charles Curtis, Charles Gordon Curtis, Cyrus Curtis, Cyrus Herman K. Curtis, Cyrus Hermann Kotzschmar Curtis, Edward Curtis, Edward Sheriff Curtis, George Ticknor Curtis, George William Curtis, Natalie Curtis, Samuel Ryan Curtis, Tony Curtiss, Glenn Curtiss, Glenn Hammond Curtius Reaction Curtius rearrangement Curtius Rufus, Quintus Curtius, Ernst Curtius, Georg Curtius, Theodor Curtiz, Michael Curvature curvature correction curvature effect curvature friction curvature of field Curvature of Image Field curvature of space Curvature of the Spine curvature tensor Curve curve fitting curve follower curve of constant bearing curve of equal bearing curve of growth Curve of Pursuit curve resistance curve tracer curve tracing Curve, Quadratic			Curtis, Charles Gordon Curtis, Cyrus Curtis, Cyrus Herman K. Curtis, Cyrus Hermann Kotzschmar Curtis, Edward Curtis, Edward Sheriff Curtis, George Ticknor Curtis, George William Curtis, Natalie Curtis, Samuel Ryan Curtis, Tony Curtisia Curtisia dentata Curtisiaceae Curtiss Curtiss Hall Banquet Center Curtiss SB2C-1 Helldiver, USAAF Version of Single-Engine Dive Bomber Curtiss Wright Embedded Computing Curtiss, Glenn Curtiss, Glenn (Hammond) Curtiss, Glenn Hammond Curtiss-Wright Controls Embedded Computing Curtiss-Wright Flow Control Curtius reaction Curtius rearrangement Curtius Rufus, Quintus Curtius, Ernst Curtius, Georg Curtius, Theodor Curtiz, Michael curtly curtly Curtly Ambrose curtness curtness Curto prazo Curtosis Curtosis Curtosis Curtosis CURTS curtsey curtseyed curtseying curtseys curtsied curtsies curtsy curtsy curtsy to curtsying Curtun Curtun Curu River Reservoir Fisheries CURUFC

Curtius Reaction (redirected from Curtius rearrangement)

Curtius Reaction
(redirected from Curtius rearrangement)