The patient's Cushing disease
is currently in remission and her amenorrhea is resolving, with the additional symptoms of hyperandrogenic hypogonadism improving over time.
In Cushing disease
, transsphenoidal resection of the pituitary adenoma offers the best chance of cure (9).
Cushing described basophilic adenomas of the pituitary associated with Cushing disease
and described Cushing syndrome--the clinical effects of hyperadrenalism.
We identified a subset of 21 patients who had undergone pituitary surgery for Cushing disease
and had remained at our center for postoperative surveillance.
Another example is corticotropin (ACTH)  as the trophic hormone paired with cortisol as the target hormone for Cushing disease
(hyperfunction) and Addison disease (hypofunction).
2 FAI 8 Secondary adrenal insufficiency ADE 33 182 MER 36 124 Adrenal adenoma TUR 1377 1258 ORT 1145 1068 Mean [+ or -] SD 973 [+ or -] 266 (n = 10) Range 568-1377 Cushing disease
MON 411 4389 LAN 372 3925 Ectopic ACTH secretion BRE 9865 MOR 1574 IMO 786 Mean [+ or -] SD 2959 [+ or -] 3874 (n = 5) Range 786-9865 Cushing disease
under OP'DDD MON 282 Ectopic ACTH under OP'DDD BRE 569 MOR 358 Chronic renal insufficiency Mean [+ or -] SD 387 [+ or -] 98 (n = 10) Range 265-568 11-HSD deficiency GON J-C 215 GON A 193 GON A (c) 146 Serum E, nmol/L [t.
Two of the patients had primary adrenal insufficiency (Addison disease), two had secondary adrenal insufficiency (hypopituitarism),10 had adrenal adenoma, two had Cushing disease
, five had ectopic ACTH secretion, 10 were hypertensive patients with CRI, and two were cases of 11[beta]-OH steroid dehydrogenase deficiency (AME-1).