The clear difference in respiratory activity between control and complex I-deficient cybrids (Fig.
This was illustrated in particular by the cybrid cells.
We have been using cybrid
studies to evaluate inheritance patterns in RC disorders (10), which requires isolation and evaluation of many clones (>20).
Cybrids were initially used to study issues of heteroplasmy and threshold for known diseases of mtDNA point mutation, such as MELAS and MERRF.
138) Alzheimer disease cybrids also exhibit oversecretion of [beta]-amyloid protein.
Players assume command of an army of Bioderms, classified as non-human warrior pilots created in bio-vats, charged with defeating enemy cybrids
EarthSiege 2 puts players in charge of a squadron of mighty Herculean, pilotable robots capable of destroying enemy Cybrids with a single shot.
The robotic combat simulation game, which challenges players to conquer Cybrid forces to save the Earth, features an all-new RAZOR aircraft and mighty new HERCs in stunning SVGA combat fields, so now you can fly and fight as well as battle on the ground.
Cybrids may be used as models for diseases associated with mitochondrial dysfunction.
Cybrids are created by transferring mitochondria and mitochondrial DNA into rho-zero cells.
Complex I activity was 20 percent lower in the Parkinson's disease (PD) cybrids as compared to the controls.
To test the theory, the researchers developed proprietary cybrid (cytoplasmic hybrid) cell lines to model the mitochondrial DNA of Parkinson's patients.