Seeking structural parameters that might enhance antifungal activity, we introduced chlorine, methoxy, and methyl substituents onto the 2,4-diaryl 1,2,3,4-tetrahydroquinoline ring; we also used two different dienophiles for the cycloaddition reaction
(anethole and isoeugenol) and performed N-debenzylation of the tetrahydroquinoline derivatives 5a-h.
SYNTHESIS OF ISOXAZOLINES AND ISOXAZOLES VIA 1, 3-DIPOLAR CYCLOADDITION REACTIONS IN AQUEOUS MEDIA: A GREEN APPROACH
These compounds were synthesized by cycloaddition reaction
starting from the commercially available 3-nitroanilines 1, benzaldehyde 2, and trans-anethole, according to the literature procedure (Kouznetsov et al.
No racemization was observed in the synthesized homopolymers and copolymers, because of the quasi-living character of this type of cycloaddition reaction
, as previously reported (14-16), (26-28); the racemization by transesterification reaction should be characterized by the presence of multiple carbonyl peaks (170.
In the Emerging Organic Synthesis Symposium, graduate student Ian Young, ACIC, presented work he has carried out with Michael Kerr, MCIC, at the University of Western Ontario in the development of a new cycloaddition reaction
, in which nitrones and cyclopropanes are coupled to make highly functionalized heterocycles.
11:00 HPLC OF METALLIC NITRIDE FULLERENE (MNF) CYCLOADDITION REACTION
Vollhardt also employed a cycloaddition reaction
, but in this case, it was a metal-mediated [2 + 2 + 2] cycloaddition, which led to the shortest overall route, 14 steps from propiolic acid.
The [2+2] photo-induced cycloaddition reaction
of cinnamic acid derivatives, which leads to crosslinking in polymer systems, is the basis of commercial negative photo-resists (1-3).
9:15 ORGANIC SYNTHESIS AND CHROMATOGRAPHIC SEPARATION OF [4+2] CYCLOADDITION REACTION
PRODUCTS FROM METALLIC NITRIDE FULLERENE (MNF) NANOMATERIALS
Lautens's contribution to the field has focused on the synthesis of novel monomers using a cobalt-catalyzed cycloaddition reaction
between norbornadiene and an acetylene to generate compounds known as deltacyclenes.
3,5- Dibromoindene-1-one (6) underwent an intramolecular [2+4] cycloaddition reaction
in which cyclopentadienone structure acted as both diene and dienophile.
11 Functional Nanomaterials using the Cu-catalyzed Huisgen cycloaddition reaction