Two formats are envisioned for the synthesis of tricyclic peptides: in the first one, a linear peptide is anchored via four cysteine residues to a small molecule while in the second format, bicyclic peptides will be generated and their two peptide rings are connected via Huisgen cycloaddition reaction
to impose an additional conformational constraint.
Many types of reactions have been reported including the monoesterification and transesterification reactions of carboxylic acids (6-8), decarboxylation-induced crosslink reaction (9), imide ring-opening reaction (10-12), graft crosslink with etherification reaction (4), (13), ultra violet crosslink (14-16), acetylenes of a Diels-Alder-type cycloaddition reaction
(17-19), and crosslink using dendrimer (20), (21).
His design employs either polyesters (more sustainable due to access to bio-based raw materials) or poly-imides (for high-temperature applications) that are functionalized with cyclobutane substrates through the photochemistry of maleic anhydrides, which undergo a [2[Plus]2] cycloaddition reaction
to form cyclobutanes when exposed to one wavelength of light and the reverse when exposed to another.
We investigated the incorporation of water soluble Lewis acids that promote a 1, 3-dipolar cycloaddition reaction
between organic molecules in water.
These polymers have gained a huge interest academically in recent years as the azide group can undergo a cycloaddition reaction
with a terminal alkyne group in presence of a Cu(I) catalyst to make block, graft, brush, and star polymers.
Philip Dawson, a member of Faculty of 1000 Biology and leading authority in chemistry and cell biology, reviewed a study and observed that the novel cycloaddition reaction
is fast, very specific, and requires minimal manipulation of the cells.
No racemization was observed in the synthesized homopolymers and copolymers, because of the quasi-living character of this type of cycloaddition reaction
, as previously reported (14-16), (26-28); the racemization by transesterification reaction should be characterized by the presence of multiple carbonyl peaks (170.
In the Emerging Organic Synthesis Symposium, graduate student Ian Young, ACIC, presented work he has carried out with Michael Kerr, MCIC, at the University of Western Ontario in the development of a new cycloaddition reaction
, in which nitrones and cyclopropanes are coupled to make highly functionalized heterocycles.
11:00 HPLC OF METALLIC NITRIDE FULLERENE (MNF) CYCLOADDITION REACTION
Vollhardt also employed a cycloaddition reaction
, but in this case, it was a metal-mediated [2 + 2 + 2] cycloaddition, which led to the shortest overall route, 14 steps from propiolic acid.
The [2+2] photo-induced cycloaddition reaction
of cinnamic acid derivatives, which leads to crosslinking in polymer systems, is the basis of commercial negative photo-resists (1-3).
9:15 ORGANIC SYNTHESIS AND CHROMATOGRAPHIC SEPARATION OF [4+2] CYCLOADDITION REACTION
PRODUCTS FROM METALLIC NITRIDE FULLERENE (MNF) NANOMATERIALS