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cyclophilin

   Also found in: Acronyms, Wikipedia 0.01 sec.
cyclophilin [‚sī·kə′fil·ən]
(biochemistry)
An abundant cytoplasmic protein that catalyzes cis-trans isomerizations; it has a high affinity for the immunosuppressive drug cyclosporin A.


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Lead researcher Jeremy Luban points out that owl monkeys make AoT5Cyp, and that the human genome encodes the equivalent of the two components of this fusion protein, namely TRIM5 and cyclophilin A.
SCY-635, a novel cyclophilin inhibitor, represents a new pharmacological class of inhibitors of hepatitis C virus (HCV) replication.
Bourdette reported at the 2008 Society for Neuroscience meeting that deactivating cyclophilin D--a key protein in mitochondria--was crucial to keeping the balance of calcium steady within nerve cells.
 
 
 
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