cyclophilin

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cyclophilin

[‚sī·kə′fil·ən]
(biochemistry)
An abundant cytoplasmic protein that catalyzes cis-trans isomerizations; it has a high affinity for the immunosuppressive drug cyclosporin A.
References in periodicals archive ?
It targets a group of enzymes called cyclophilins, which play an important role in the development of acute inflammation.
Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.
Scientific research continues to validate cyclophilins as key disease-modifying targets in the treatment of a wide range of indications from myocardial infarction and virology to central nervous system disorders.
The researchers say that they analysed liver cells to determine which variant of cyclophilins is critical for hepatitis C virus replication, and found that blocking cyclophilin A leads complete inhibition of virus replication.
Cyclophilins are a family of enzymatic proteins that assist in the folding and transport of other proteins synthesized within a cell.
Debio 025 binds strongly to cyclophilins, host cell proteins thought to confer a replication advantage to HCV.
Thus, 10 cyclophilins wind up facing outward, with 10 cyclosporins sandwiched between them.
The ability of these drugs to inhibit CN activity is dependent on them binding to their respective immunophilins, cyclophilins A and B for CsA and FKBP12 for tacrolimus (2, 3).
Debio-025 binds strongly to cyclophilins, host cell proteins thought to confer a replication advantage to HCV.
To inhibit CNA, CsA and TRL must bind to the immunophilins present in the cytoplasm of T lymphocytes: cyclophilins in the case of CsA and FK-binding proteins (FKBPs) in the case of TRL.
3) Among the three families making up this enzyme class, cyclophilins (Cyps) have been characterized as receptors for the immunosuppressant cyclosporin A, whereas a second PPIase family, the FK506 binding proteins (FKBPs), represents cellular receptors for the immunosuppressive peptidomacrolide FK506 [2-4].
Cyclophilins assist in the folding and transport of other proteins synthesized within a cell.