cyclooxygenase

(redirected from Cycloxygenase)
Also found in: Dictionary, Thesaurus, Medical.
Related to Cycloxygenase: Cyclooxygenase 2 inhibitors

cyclooxygenase

[‚sī·klō′äks·ə·jə‚nās]
(biochemistry)
An enzyme that catalyzes the conversion of arachidonic acid into prostaglandins.
Mentioned in ?
References in periodicals archive ?
Prostaglandins are generated from arachidonic acid via the cycloxygenase (cox) pathway.
19 TQ also inhibits the synthesis of prostaglandins (PGEs) and LTs by blocking the cycloxygenase (COX) and lipoxygenase (LO) pathways of arachidonate metabolism, and is thus responsible for anti- inflammatory activity.
Curcumin decrease cycloxygenase 2 expression and decreases serum leptin levels and thereby attenuates the risk of developing pre-malignant lesions in colon tissue (Kubota et al.
Different factors such as free radical and ROS scavenging, tissue necrosis factor (TNF)-a inhibition, cycloxygenase pathway activation, and endothelial nitric oxide synthase activation were found to be responsible for cardiovascular protective effect.
Subsequently neutrophils, macrophages and polymorphonuclear leukocytes produce and release inflammatory mediators such as oxygen-flee radicals, proteolytic enzymes, and cycloxygenase and lipoxygenase metabolites of arachidonic acid.
Suppressive effect of natural sesquiterpenoids on inducible cycloxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophase cells.
Natural products like esculetin, fraxetin, daphnetin and other related coumarin derivatives are recognized as inhibitors of the lipoxygenase and cycloxygenase enzymic systems, and of neutrophil-dependent superoxide anion generation (Fylaktakidou et al.