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Cystathionine

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Cystathionine 

(also 2,7-diamino-4-thiasuberic acid), HOOCCH(NH2)CH2CH2SCH2CH(NH2)COOH, an amino acid containing a sulfide group. Cystathionine is an important intermediate in the biosynthesis and metabolism of amino acids containing sulfur. Of the four optically active and two racemic forms of the acid, only L-cystathionine and L-allo-cystathionine are biologically active. In mammals, L-cystathionine participates in the biosynthesis of cysteine from methionine and serine; in plants and bacteria, it participates in the biosynthesis of methionine from cysteine and homoserine.



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7) Vitamin B6 Vitamin B6 is a coenzyme for the conversion of homocysteine to nontoxic cystathionine, and deficiency of the vitamin is associated with abnormal homocysteine metabolism.
The latter is fist converted to homocysteine, which is then combined with serine to form cystathionine.
Excess homocysteine also occurs in response to remethylation deficits and a deficiency of an enzyme called cystathionine b-synthase.
 
 
 
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