cytomegalovirus

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cytomegalovirus

(sī'təmĕg'əlōvī`rəs), member of the herpesvirus family that can cause serious complications in persons with weakened immune systems and infants. A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach adulthood. Most experience no symptoms or mild symptoms such as enlarged lymph nodes, low fever, and fatigue that may or may not be noticed. Cytomegalovirus is present in body fluids (saliva, semen, cervical secretions, and urine) and can be spread from person to person by sexual contact, kissing, or the sharing of food. It can also be transmitted from mother to fetus. The virus usually remains dormant in the body, but it can reactivate and cause serious symptoms in immunologically suppressed patients, such as those with AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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, or in infants whose immune systems are not yet fully developed. An estimated 25% of AIDS patients experience CMV infection, often in the form of a viral retinitis that can lead to blindness. Infants can become infected before birth when the mother becomes infected or experiences a recurrence during pregnancy. In a newborn, CMV can be life-threatening, and it can lead to later complications such as cerebral palsy, blindness, hearing problems, mental retardation, and learning disabilities. The antiviral drugs foscarnet and ganciclovir are used to keep active infections under control.

cytomegalovirus

[¦sīd·ō¦meg·ə·lō′vī·rəs]
(virology)
An animal virus belonging to subgroup B of the herpesvirus group; causes cytomegalic inclusion disease and pneumonia.
References in periodicals archive ?
Cytomegalovirus urinary excretion and long term outcome in children with congenital cytomegalovirus infection.
Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review.
Patients with low-grade cytomegalovirus infection had median 2-year survival rates of 63.
Update on the prevention, diagnosis and management of cytomegalovirus infection during pregnancy.
Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women.
Seroepidemiology of cytomegalovirus infection in and around Chandigarh.
Cytomegalovirus infection in critically ill patients: associated factors and consequences.
Key words: Cytomegalovirus infection, diagnosis, urine, inhibitors, extraction, DNA, Ethylene glycol.
Comparison of polymerase chain reaction from plasma and buffy coat with antigen detection and occurrence of immunoglobulin M for the demonstration of cytomegalovirus infection after liver transplantation.
Oral opportunistic viral infections include herpes simplex infections, oral hairy leukoplakia, varicella-zoster infections, cytomegalovirus infections and oral warts.