dynein

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dynein

[dī′nē·ən]
(cell and molecular biology)
A large enzyme complex that hydrolyzes adenosine triphosphate to provide energy to power retrograde [from (+) to (-)] transport along microtubules.
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Her research focused on cytoplasmic dynein, a motor protein that drives intracellular transport.
In addition, alternative splicing forms of cytoplasmic dynein 1 (DYNCl), AXL receptor tyrosine kinase (AXL), pleckstrin homology domain containing, family G (with RhoGef Domain) member 1 (PLEKHG1), and the cordon-bleu WH2 repeat protein-like 1 (COBLL1) showed reversed expression patterns before and after exercise in skeletal muscle (Park et al.
Objective: The megadalton cytoplasmic dynein complex, whose motor subunit is encoded by a single gene, provides the major microtubule minus end-directed motility in cells and is essential for a wide range of processes, ranging from the transport of proteins, RNA, and membrane vesicles to nuclear migration and cell division.
Moreover, dynactin (dynein activator), another multisubunit complex, co-fractionates with cytoplasmic dynein and further is required for cytoplasmic dynein-based motility functions in vivo and in vitro.

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