cytotoxic T cell

(redirected from Cytotoxic T lymphocyte)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection.
In addition, BGB324 + anti-CTLA-4/anti-PD-1 treated tumours displayed enhanced infiltration of cytotoxic T lymphocytes.
Cytotoxic T lymphocytes also lyse HIV-infected cells and secrete HIV-suppressive factors.
To accomplish these duties, various types of T cells are used, including helper T cells (T-helper cells) and cytotoxic T lymphocytes (CTLs).
These approaches include biologic therapy using interleukin (IL)-2, IL-12, interferon-alpha, monoclonal antibodies directed against B cell targets, cytotoxic T lymphocytes directed against viral targets, immune-based therapy, stem cell reconstitution, angiogenesis inhibitors, therapeutic vaccines, and traditional cytotoxic chemotherapy regimens (often in combination with a biologic or immunologic approach).
OUR bodies naturally produce special killer cells, known as cytotoxic T lymphocytes or CTLs, which target tumours and cells infected with viruses.
Non-personalized HIV immunotherapies are unable to raise cytotoxic T lymphocytes against HIV antigens, fail to induce T cell memory, and, most importantly, do not provide antiviral protection against the patient's own particular virus," said Jean-Pierre Routy, M.
Our data suggest that individuals who were infected with seasonal human influenza A viruses previously or who received seasonal human influenza vaccines may derive benefit, at least in part, from the preexisting cross-reactive memory cytotoxic T lymphocytes to reduce the severity of pdmH1N1 infection even without protective antibodies," said the researchers.
Heterosubtypic immunity to influenza A virus infection requires B cells but not CDS+ cytotoxic T lymphocytes.
ALVAC-HIV induces the proliferation of cytotoxic T lymphocytes and contains genes coding for glycoprotein 120 and other HIV components in a canarypox vector.
Studying a dozen people with HIV, the scientists found that those who progressed quickest to AIDS had relatively few virus-killing immune cells, known as cytotoxic T lymphocytes, that recognize Tat.
Full browser ?