Functionally inert HIV-specific cytotoxic T lymphocytes
do not play a major role in chronically infected adults and children.
Memory and distribution of virus-specific cytotoxic T lymphocytes
(CTLs) and CTL precursors after rotavirus infection.
In addition, BGB324 + anti-CTLA-4/anti-PD-1 treated tumours displayed enhanced infiltration of cytotoxic T lymphocytes
Cytotoxic T lymphocytes
also lyse HIV-infected cells and secrete HIV-suppressive factors.
To accomplish these duties, various types of T cells are used, including helper T cells (T-helper cells) and cytotoxic T lymphocytes
These approaches include biologic therapy using interleukin (IL)-2, IL-12, interferon-alpha, monoclonal antibodies directed against B cell targets, cytotoxic T lymphocytes
directed against viral targets, immune-based therapy, stem cell reconstitution, angiogenesis inhibitors, therapeutic vaccines, and traditional cytotoxic chemotherapy regimens (often in combination with a biologic or immunologic approach).
OUR bodies naturally produce special killer cells, known as cytotoxic T lymphocytes
or CTLs, which target tumours and cells infected with viruses.
Non-personalized HIV immunotherapies are unable to raise cytotoxic T lymphocytes
against HIV antigens, fail to induce T cell memory, and, most importantly, do not provide antiviral protection against the patient's own particular virus," said Jean-Pierre Routy, M.
Our data suggest that individuals who were infected with seasonal human influenza A viruses previously or who received seasonal human influenza vaccines may derive benefit, at least in part, from the preexisting cross-reactive memory cytotoxic T lymphocytes
to reduce the severity of pdmH1N1 infection even without protective antibodies," said the researchers.
Heterosubtypic immunity to influenza A virus infection requires B cells but not CDS+ cytotoxic T lymphocytes
ALVAC-HIV induces the proliferation of cytotoxic T lymphocytes
and contains genes coding for glycoprotein 120 and other HIV components in a canarypox vector.
Studying a dozen people with HIV, the scientists found that those who progressed quickest to AIDS had relatively few virus-killing immune cells, known as cytotoxic T lymphocytes
, that recognize Tat.