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lymphocyte
(redirected from Cytotoxic T lymphocytes)

    Also found in: Dictionary/thesaurus, Medical, Acronyms, Wikipedia, Hutchinson 0.06 sec.
lymphocyte: see blood blood, fluid pumped by the heart that circulates throughout the body via the arteries, veins, and capillaries (see circulatory system ; heart ). An adult male of average size normally has about 6 quarts (5.6 liters) of blood.
..... Click the link for more information. ; immunity immunity, ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information. .

lymphocyte

Enlarge picture
Human lymphocyte (phase-contrast microphotograph).
(credit: Manfred Kage—Peter Arnold)
Type of leukocyte fundamental to the immune system, regulating and participating in acquired immunity. Each has receptor molecules on its surface that bind to a specific antigen. The two primary types, B cells and T cells, originate from stem cells in bone marrow and travel to lymphoid tissues. When a B cell binds to an antigen, it multiplies to form a clone of identical cells. Some of these, acted on by helper T cells, differentiate into plasma cells that produce antibodies against the antigen. Others (memory cells) multiply, providing long-term immunity to the antigen.
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The most important effectors of the cell-mediated immune response, cytotoxic T lymphocytes, are the main immune cells that recognize foreign antigens on the surface of infected "self" cells.
Emerging infections and pregnancy by Rasmussen, Sonja A. / Emerging Infectious Diseases
These approaches include biologic therapy using interleukin (IL)-2, IL-12, interferon-alpha, monoclonal antibodies directed against B cell targets, cytotoxic T lymphocytes directed against viral targets, immune-based therapy, stem cell reconstitution, angiogenesis inhibitors, therapeutic vaccines, and traditional cytotoxic chemotherapy regimens (often in combination with a biologic or immunologic approach).
Cancer and AIDS: National Cancer Institute's investment in research by Black, Jodi B. / Research Initiative/Treatment Action!
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.
New Finding on Immune Response to HIV Tat May Contribute to Vaccine, ... by James, John S. / AIDS Treatment News
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