cytotoxic T cell

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cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Both CD4 T-helper cells and cytotoxic T-cells that respond to JE virus and dengue proteins have been identified, and their epitopes have been mapped (9).
Based upon proliferative and cytotoxic T-cell responses during in vitro testing with HIV-infected human cells and successful in vivo results in a non-human primate model, we are implementing plans to move EradicAide vaccine into human testing as an HIV therapeutic vaccine later this year.
Epimmune's initial HIV vaccine candidate is composed of specific cytotoxic T-cell (CTL) epitopes, or protein fragments, which were selected from conserved regions of the HIV virus using Epimmune proprietary processes.
PPV technology could have commercial applications in the areas of HIV, HPV and mucosal tumors such as colonic and cervical cancers -- Bio-Bridge HIV-PV Vaccine I for HIV/AIDS works by stimulating two types of mucosal immune responses: Neutralizing Antibodies and Cytotoxic T-Cell Response.
Epimmune's initial cancer vaccine candidate is composed of multiple tumor-specific cytotoxic T-cell (CTL) epitopes, or protein fragments, which were selected from tumor associated antigens using Epimmune proprietary processes.
We are pleased by these data which, first of all, continue to show the safety of telomerase vaccination in cancer patients, especially in view of the strong telomerase-specific cytotoxic T-cell responses generated in the vaccinated patients," said Thomas B.
Polyclonal or oligoclonal expansion of cytotoxic T-cells often occurs early In the disease process in HIV-positive patients.
Studies have shown that T-cell vaccination resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
Studies of T-cell vaccine have indicated that T-cell vaccination with peripheral blood-derived autologous myelin-peptide selected T-cells in MS patients resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
Studies of T-cell vaccine have indicated that T-cell vaccination with peripheral blood-derived autologous myelin-peptide selected T-cells in multiple sclerosis patients resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
The study conducted by Chen and coworkers, indicated that T-cell vaccination with autologous selected synovial T-cells in rheumatoid arthritis patients resulted in the induction of CD4+ Tregs and CD8+ cytotoxic T-cells specific for T-cell vaccine.
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