cytotoxic T cell

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cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Once the epitope candidates selected by this method are confirmed in cytotoxic T-cell (CTL) assays, they may be useful for 1) screening exposed persons for T-cell responses, 2) investigating the immunopathogenesis of WN virus disease in humans, 3) as components of diagnostic kits developed for WN virus surveillance, 4) as reagents for measuring WN virus vaccine-related immune responses, and possibly 5) as components of a subunit vaccine for WN virus.
Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma: [CD3.
An ultrastructural study of cutaneous panniculitis-like T-cell lymphoma: cytoplasmic granules and active cellular and cell-to-matrix interaction mimic cytotoxic T-cells.
Polyclonal or oligoclonal expansion of cytotoxic T-cells often occurs early In the disease process in HIV-positive patients.
Studies have shown that T-cell vaccination resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
Studies of T-cell vaccine have indicated that T-cell vaccination with peripheral blood-derived autologous myelin-peptide selected T-cells in MS patients resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
Studies of T-cell vaccine have indicated that T-cell vaccination with peripheral blood-derived autologous myelin-peptide selected T-cells in multiple sclerosis patients resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
The study conducted by Chen and coworkers, indicated that T-cell vaccination with autologous selected synovial T-cells in rheumatoid arthritis patients resulted in the induction of CD4+ Tregs and CD8+ cytotoxic T-cells specific for T-cell vaccine.
As HIV disease progresses, certain immune cells called CD8 cytotoxic T-cells undergo accelerated replicative senescence (cellular aging) and lose their ability to proliferate and kill HIV-infected CD4 T-cells.
During the progression of HIV disease, certain immune cells called CD8+ cytotoxic T-cells undergo accelerated replicative senescence (cellular aging), and lose their ability to proliferate and kill HIV-infected CD4+ T-cells.
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