Active immunotherapy vaccines cause the immune system to produce cytotoxic T-cells
As HIV disease progresses, certain immune cells called CD8 cytotoxic T-cells
undergo accelerated replicative senescence (cellular aging) and lose their ability to proliferate and kill HIV-infected CD4 T-cells.
IL-21 is a novel protein that regulates a variety of cell types that include cytotoxic T-cells and natural killer cells, cell types involved in the body's ability to fight diseases, including certain cancers.
By activating cytotoxic T-cells and natural killer cells, IL-21 may enhance the body's ability to defend itself against cancer," stated Jan Ohrstrom, M.
Instead, active immunotherapy vaccines cause the immune system to produce cytotoxic T-cells
Large numbers of cytotoxic T-cells
have been discovered in certain HIV infected individuals who remain well for many years.
During the progression of HIV disease, certain immune cells called CD8+ cytotoxic T-cells undergo accelerated replicative senescence (cellular aging), and lose their ability to proliferate and kill HIV-infected CD4+ T-cells.
Effros confirms and extends her earlier studies with TAT0001 and TAT0002, showing that our drug candidates enhance multiple functions of the cytotoxic T-cells that keep HIV in check," stated Calvin B.
Commenting on the studies, Professor Plotnikoff stated, "In the studies conducted to date, there have been noted increases in CD8 cells, or Cytotoxic T-cells
, that attack the HIV virus.
The research, presented at the 2005 Palm Springs Symposium on HIV/AIDS, demonstrated that the Geron compounds increased the proliferative capacity of cytotoxic T-cells
and their ability to produce a virus-fighting molecule, gamma Interferon (IFN(gamma)).