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Cytoxan

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Cytoxan (sītŏk`sĭn), trade name for the drug cyclophosphamide, used to inhibit growth of tumors and rapidly proliferating cells. It is used in the treatment of leukemia, Hodgkin's disease, and lymphosarcoma and other solid tumors. A drug of great specificity, Cytoxan is activated in the body by the enzymes in certain types of tumors. Because it is also activated in such tissues as blood plasma and liver, it is a highly toxic substance. Nevertheless, it is a potent and useful chemotherapeutic agent.


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A fifth possibility is Cytoxan (or cyclophosphamide), which some studies show to be effective and others indicate has no Clear benefit.
In a study involving 388 women with ovarian cancer, tumor tissue shrank or disappeared in 73 percent of women taking taxol and cisplatin, compared with 59 percent of those receiving cytoxan and cisplatin, reports William P.
Off-label use of rituximab (Biogen Idec/Genentech's Rituxan), currently in Phase III for CLL, has had significant success in combination with fludarabine and cyclophosphamide (Bristol-Myers Squibb's Cytoxan, Baxter's Endoxan/Endoxana, Pfizer's Neosar/Cyclostin, generics) in previously untreated patients, and we expect its adoption to increase when rituximab is approved.
 
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