Cytoxan


Also found in: Dictionary, Medical, Acronyms, Wikipedia.
Related to Cytoxan: Taxol

Cytoxan

(sītŏk`sĭn), trade name for the drug cyclophosphamide, used to inhibit growth of tumors and rapidly proliferating cells. It is used in the treatment of leukemia, Hodgkin's disease, and lymphosarcoma and other solid tumors. A drug of great specificity, Cytoxan is activated in the body by the enzymes in certain types of tumors. Because it is also activated in such tissues as blood plasma and liver, it is a highly toxic substance. Nevertheless, it is a potent and useful chemotherapeutic agent.
References in periodicals archive ?
In that context we have a confirmation that Cytoxan works and that immuno-suppression helps," he said.
The patient was started on IV cytoxan per NIH protocol.
Patients with CNS lymphoma are treated with the methotrexate, etoposide phosphate and cytoxan regimen.
Howard Weiner of Brigham and Women's Hospital in Boston presented data showing that booster shots of intravenous Cytoxan, given every two months over two years after the initial Cytoxan treatment, allowed a subgroup of patients to become more stable than those who received no boosters.
Data Demonstrate Cytoxan Preconditioning Combined with CD4/CD8 ZFN-modified T-cell Product Reduces Viral Load to Limit of Quantification in One Subject of Three; Delays Onset of Viremia in Another Subject
Another main class of pharmaceutical interventions for RA, known as disease-modifying anti-rheumatic drugs (DMARDs), include methotrexate, cyclosporine, and cytoxan.
TABLE Characteristics of 3 Patients With Refractory Immune Thrombocytopenic Purpura Pretreatment Case Age/Sex Previous Treatments Platelets/[micro]L 1 49/F Prednisone, splenectomy, IVIC, <10,000 WinRho, cyclosporin A, Cytoxan, Cellcept 2 87/F Prednisone, WinRho, <15,000 vincristine, IVIG 3 75/M Prednisone, IVIG, WinRho <20,000 Posttreatment Duration of Highest Response Case Platelets/[micro]L (months) Retreatment 1 37,000 6 Yes 2 175,000 [less than or equal to]3 No 3 59,000 [less than or equal to]7 No
The patient underwent induction and consolidation chemotherapy according to the Southwest Oncology Group protocol 9400: daunorubicin, vincristine, prednisone, L-asparaginase, cytoxan, arabinoside-C, 6-mercaptopurinol, and methotrexate.
Sangamo has an ongoing Phase 2 clinical trial (SB-728-mR-1401) which incorporates Cytoxan preconditioning of subjects and a new, more efficient method using mRNA to deliver the ZFNs and generate the modified autologous T-cell product, SB-728-T.
The patient was treated with steroids, monthly pulse dose cytoxan, and aggressive physical therapy.
Subsequently, the patient had a spontaneous right retroperitoneal and left upper extremity hemorrhage and required factor VIII transfusions, high-dose corticosteroids and oral cytoxan.
The Company holds an exclusive world-wide license to Revimmune from Johns Hopkins University and has a strategic agreement with Baxter Healthcare Corporation covering the commercialization of Cytoxan, the active ingredient of Revimmune, for the treatment of a range of autoimmune diseases including multiple sclerosis and the prevention of graft-versus-host disease following bone marrow transplant.