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The Pediatric Cancer Genome Project found that DDX3X was mutated in a high percentage of patients with the wingless (WNT) subtype of medulloblastoma.
Now scientists have determined the DDX3X mutations lead to different molecular defects.
Our research indicates that mutations of DDX3X do not all lead to a common defect in cells," said Eric Enemark, Ph.
In this study, scientists used a variety of biochemical, genetic and structural techniques to identify the molecular defects associated with two of the DDX3X mutations associated with medulloblastoma.