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DNA
(redirected from DNA deletion)

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DNA: see nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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DNA

 or deoxyribonucleic acid

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DNA double helix. A. Molecular model of DNA. The molecules include (1) hydrogen, (2) oxygen (3) …
(credit: © Merriam-Webster Inc.)
One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. Its structure, with two strands wound around each other in a double helix to resemble a twisted ladder, was first described (1953) by Francis Crick and James D. Watson. Each strand is a long chain (polymer) of repeating nucleotides: adenine (A), guanine (G), cytosine (C), and thymine (T). The two strands contain complementary information: A forms hydrogen bonds (see hydrogen bonding) only with T, C only with G. When DNA is copied in the cell, the strands separate and each serves as a template for assembling a new complementary strand; this is the key to stable heredity. DNA in cells is organized into dense protein-DNA complexes (see nucleoprotein) called chromosomes. In eukaryotes these are in the nucleus, and DNA also occurs in mitochondria and chloroplasts (if any). Prokaryotes have a single circular chromosome in the cytoplasm. Some prokaryotes and a few eukaryotes have DNA outside the chromosomes in plasmids. See also Rosalind Franklin; genetic engineering; mutation; Maurice Wilkins.


DNA
(1) See Windows DNA.

(2) (Digital Network Architecture) Introduced in 1978, it was Digital's umbrella term for its enterprise network architecture based on DECnet.
DNA
deoxyribonucleic acid; a nucleic acid that is the main constituent of the chromosomes of all organisms (except some viruses). The DNA molecule consists of two polynucleotide chains in the form of a double helix, containing phosphate and the sugar deoxyribose and linked by hydrogen bonds between the complementary bases adenine and thymine or cytosine and guanine. DNA is self-replicating, plays a central role in protein synthesis, and is responsible for the transmission of hereditary characteristics from parents to offspring

DNA
(biochemistry)


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Mental retardation is caused by many different, yet individually rare DNA deletions and duplications.
In a second study of 18 lung and breast cancer cell lines, Meyerson's research team found copy number amplifications (encompassing known proto-oncogenes) and deletions (encompassing TSGs), and distinguished LOH caused by a DNA deletion coupled with a gene mutation (13).
However, by using a prototype plasmid-based microarray that covered 10% of the genome, we found multiple genomic DNA deletions among 30 M.
 
 
 
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