DNA

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Related to DNA gyrase: Topoisomerase, Quinolones

DNA:

see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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DNA (deoxyribonucleic acid)

See GENETICS.

DNA

(biochemistry)

DNA

deoxyribonucleic acid; a nucleic acid that is the main constituent of the chromosomes of all organisms (except some viruses). The DNA molecule consists of two polynucleotide chains in the form of a double helix, containing phosphate and the sugar deoxyribose and linked by hydrogen bonds between the complementary bases adenine and thymine or cytosine and guanine. DNA is self-replicating, plays a central role in protein synthesis, and is responsible for the transmission of hereditary characteristics from parents to offspring

DNA

(1) See Windows DNA.

(2) (Digital Network Architecture) Introduced in 1978, it was Digital's umbrella term for its enterprise network architecture based on DECnet.
References in periodicals archive ?
36 Kcal/mol for DNA gyrase, showed hydrogen bonds through Glu139, Arg176, and non-bonding interactions through His150, Phe160, Tyr141, Try76, Glu72, Lys73 and Trp76, while (2b) have E-value of -322.
Topoisomerase IV lacks the ability to introduce negative supercoils into DNA, a function that is unique to DNA gyrase.
Reduced susceptibility to fluoroquinolones is usually associated with point mutations in the bacterial target genes encoding DNA gyrase and/ or DNA topoisomerase IV within the 'quinolone resistance determining region' (QRDR).
Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque, Nat Struct Mol Biol 2007; 14 (4): 264-271.
leprae is GCA [right arrow] GTA in codon 91 of gyrA resulting in the substitution of valine for alanine (Ala91Val) in the [alpha]-subunit of the DNA gyrase.
Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.
Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity.
The main mechanisms of resistance to fluoroquinolone agents are alterations on DNA gyrase subunits and reduced penetration associated with decreased outer membrane protein production.
002% as an antibiotic which inhibits cross-wall formation upon cell division by inhibiting DNA gyrase and terminating DNA polymerization.
DNA gyrase is composed of two A (GyrA) and two B (GyrB) subunits encoded by gyrA and gyrB genes.
An Escherichia coli DNA topoisomerase I mutant has a compensatory mutation that alters two residues between functional domains of the DNA gyrase A protein.
The key classes of mechanism of action of drugs include ATP synthase inhibitors, protein synthesis inhibitors, cell wall synthesis inhibitors, DNA gyrase inhibitors, FAS synthase inhibitors, translocase-1 inhibitors and others.