Instead, in vivo DNA replication methods for most organisms rely on a class of enzymes known as DNA helicases
, which act to locally unwind dsDNA to create small ssDNA regions suitable for polymerase activity.
Disease variants of the human mitochondrial DNA helicase
encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis and helicase activity.
For seven years (1994-2001), AGENE conducted research aimed at clarifying the mechanism of human aging and extensively studied several genetic disorders that are caused by the mutation of DNA helicases
and show premature aging phenotypes, including Werner syndrome.
Interactions between DNA helicases
and frozen topoisomerase IV-quinolone-DNA ternary complexes.
with DNA helicase
inhibitors against Exhibit Hall A-B, #12