The book is divided into 15 chapters that can be broadly grouped under DNA microarrays
, antibody microarrays and immunoassays, and methods to optimize sample quality as well as the resulting data.
Bochner's next invention came during the genomics era, when DNA microarrays
allowed scientists to measure the expression of thousands of genes simultaneously.
The primary market for DNA microarrays
remains academia, although genotyping and gene expression applications have made inroads in pharmaceutical labs.
A DNA chip, or DNA microarray
, is a small glass slide that can reveal the presence or absence of particular DNA sequences in a sample.
are microchips which are capable of scrutinising the activity of hundreds of genes at once - dramatically speeding up the pace of research.
Mergen Limited (San Leandro, CA), a leader in oligo-based DNA microarray
technology, has entered into an agreement with Oxford Gene Technology resolving the patent infringement litigation between the companies.
Pantano indicates that research on coatings for DNA microarrays
is driven by the need to put more spots on each slide so that more potential drugs or genes can be tested at once.
This is important since fluorescent markers are regularly used with DNA microarrays
, requiring that the fluorescence of the glass and coating be minimal.
The use of DNA microarrays
is central to the new functional genomic approach being developed by several research groups at the institute and will allow scientists to study the expression of all genes in a bacterium in a single experiment--4290 genes in the case of E.
Editors Moretti and Rizzo (no affiliations listed) have collected research in the field on the use of oligonucleotides for detecting complementary DNA and RNA such as in DNA microarrays
and the synthesis of artificial genes.
Based in Witterswil, Switzerland, Zeptosens, a 1998 spin-off of Novartis, sells the ZeptoMARK protein microarrays, SensiChip DNA microarrays
and SensiChip DNA microarray
system based on fluorescence detection on the surface of a planar optical waveguide.
Innovative manufacture, miniaturization, scanning, and statistical analyses of DNA microarrays
have yielded sequence and gene expression information with remarkable throughput.