We applied genomewide bisulfite sequencing (13-17) to the analysis of cell-free fetal DNA molecules
found in the circulation of pregnant women (18).
Once we have made this dimer building block we incorporate it into a DNA duplex via solid-phase oligonucleotide synthesis using a DNA synthesizer which allows us to assemble relatively small DNA molecules
in a sequence specific manner.
Preparation of DNA molecules
is relatively easy and reproducible, and the material is very safe," said Yan Chen, a UF chemistry doctoral student and one of the authors of the paper.
In order to begin unraveling the double-stranded DNA molecule
, Top 1 first clamps onto the spiraled DNA molecule
like a pair of C-shaped pliers grasping a twisted cable.
For practical applications, customized DNA molecules
could be attached to the cantilevers, where they would fish out particular DNA sequences in, say, a blood sample, from a patient, explains coinvestigator Rob Ilic.
In nature, an enzyme called DNA polymerase replicates the genetic material by moving along one of the molecule's two strands, all the while adding complementary bases to form a new DNA molecule
Saticov, CA) has patented a chimeric recombinant DNA molecule
comprising: a plurality of DNA sequences, each of which comprises a plant-functional promoter linked to a coding region, which encodes a virus-associated coat protein, wherein said DNA sequences are preferably linked in tandem so that they are expressed in virus-susceptible plant cells transformed with said recombinant DNA molecule
to impart resistance to said viruses; as well as methods for transforming plants with the chimeric recombinant DNA molecule
and for selecting plants which express at least one of said DNA sequences imparting viral resistance.
AMEX: IPI) today announced a notification from the European Patent Office of an intention to grant a fundamental patent that covers the DNA molecule
and methods for recombinant production of Bactericidal/Permeability Increasing Protein (BPI) and fragments thereof.
Paired nucleotides would continue to stack up, interspersed with midwives, and ultimately form a DNA molecule
Yale University (New Haven , CT) has patented a high affinity, triplex-forming oligonucleotide and methods for use thereof wherein an oligonucleotide is used to form a triplestranded nucleic acid molecule with a specific DNA segment of a target DNA molecule
This new method will enable the production of large pools of beads with a unique DNA molecule
on each bead and the protein or proteins encoded by that DNA molecule
attached to the same bead.
Alameda, CA) present proof of principle for the concept of delivering a protein drug in the form of a DNA plasmid, a small circular DNA molecule
that can be swallowed.