DNA vaccine

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DNA vaccine

[¦de¦en¦ā vak′sēn]
(immunology)
A type of noninfectious vaccine that directly injects deoxyribonucleic plasmids that express antigens of interest, resulting in foreign protein expression within the cells of the vaccine; however, the vaccine itself is unable to replicate.
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The results from these trials can be used to analyze the outlook on the containment or curing of Zika and the importance of the DNA vaccination for years to come.
APCs are critical for initiating and modulating Band T-cell responses elicited by DNA vaccination.
Using these concepts, we propose to extend this principle to Schmallenberg virus, in order to: i) develop an easy-to-use diagnostic test for Schmallenberg detection; and ii) develop a DNA vaccination strategy that could be used to limit further future outbreaks.
Scientists in a wide range of biomedical disciplines survey the status of new plasmids that have emerged in the development of non-viral vectors for gene and cell therapy and DNA vaccination.
18) DNA vaccination emerged as a strong and efficient means of eliciting cell mediated and humoral responses in small animal models against a number of antigens from parasites and also from bacteria and viruses.
showed that the serum levels of IL-10 in mice were increased following DNA vaccination with recombinant chimeric tachyzoite antigens.
These new results validate the whole potential for the use of this new nanovector in DNA vaccination.
In addition regulatory agencies recognize that the open circular and linear forms of pDNA, are less effective for DNA vaccination than the supercoiled form [13].
We are excited about the promise of this treatment strategy as the DNA vaccination strategy has the potential to be applied in clinical settings in combination with other available therapeutic options.
Others consider antibiotic resistance and its detrimental impact on fish genetics, DNA vaccination and associated immunological reactions, bioconversion of lignocellulosic wastes, transgenic fish, and ethical, legal, and risk assessment issues relating to genetic engineering.
Enhancement of capsid gene expression: preparing the human papillomavirus type 16 major structural gene L1 for DNA vaccination purposes.
While research to date has found DNA vaccines to be a safe option, the long-term safety associated with DNA vaccination remains to be seen.