DNA vaccine


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DNA vaccine

[¦de¦en¦ā vak′sēn]
(immunology)
A type of noninfectious vaccine that directly injects deoxyribonucleic plasmids that express antigens of interest, resulting in foreign protein expression within the cells of the vaccine; however, the vaccine itself is unable to replicate.
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Joseph Kim, Inovio's president and CEO, said: "Inovio's goal is to revolutionalize the way new vaccine blockbusters are developed utilizing our DNA vaccine development platform, comprised of our SynCon[TM] optimized DNA vaccine constructs, novel formulations, electroporation delivery systems, and DNA manufacturing processes.
In the upcoming non-human primate study, Inovio's SynCon DNA vaccine platform, which targets sporozoites and the liver stage of the parasite, will be delivered using the company's electroporation delivery technology.
The first realistic tests of this oral DNA vaccine strategy are now under way.
According to the company, the ENABL adjuvant technology helps realize that promise through more efficient delivery of DNA-based vaccines, which results in a higher absorption of the DNA vaccine and production of antigen, as well as broader immune response.
Scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive, and easier to store than traditional vaccines.
A number of features have to be kept in mind while designing a DNA vaccine.
By establishing this partnership, Althea will be able to leverage our plasmid manufacturing expertise to help advance this DNA vaccines program through the clinic and to the patients who need it.
In this paper we describe the array of molecular assays we conducted to characterize and control the quality of gWiz HBs a hepatitis B DNA vaccine plasmid.
Vical provided the DNA vaccines for the clinical program as well as the Vaxfectin(R) adjuvant for the preclinical program.
Electroporation works like this: After a DNA vaccine is injected into the upper arm or into skin, a short, controlled electrical pulse is delivered into that tissue, either from the same needle or from a surrounding needle.
In spite of advantages of DNA vaccine strategies, a number of theoretical safety concerns may be considered for DNA vaccines.
An ImmunoBody is a DNA vaccine encoding a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells.