Food-derived Cbl species undergo dealkylation
or decyanation where their original cobalt-attached [beta] ligands are replaced with methyl or adenosyl groups to form active Cbl species, and dealkylation
of alkylcobalamins requires the thiolate of GSH for nucleophilic displacement .
We started the study on the dealkylation
mechanism around 1968, since we possessed a sizable amount of fucosterol (6), available from brown algae such as Sargassum ringgoldianum through our search for marine resources.
This behavior is ascribed to the increase in secondary cracking reaction such as dehydrogenation of components of heavy fraction of the produced oil and subsequent coke deposition, the dealkylation
, reforming reactions are also possible candidates.
on a manganese oxide surface.
2+] in the brain stems from the fact that recent studies showed that dealkylation
of Hg in the brain is not necessarily a detoxification process (40-44).
7,253,324, protecting the process for the synthesis of biologically active polyphenolic compounds by novel dealkylation
Dehydrogenation and dealkylation
reactions bring about the fusion of large aromatic structures into highly organized shapes, similar to the parallel layers of condensed planer [C.
Desethylatrazine, which is formed by microbial dealkylation
of atrazine, has a water solubility that is two orders of magnitude larger than that of atrazine - 3,200 ppm at 22 [degrees] C (Mills and Thurman 1994) - and is as persistent as the parent compound (Thurman et al.
In aerobic soils, it is much longer lived, undergoing oxidative dealkylation
over a period of months to years, depending on conditions.
Thus, it is possible that dealkylation
of these drugs could also cause false-positive amphetamine results, but this supposition remains to be shown directly.
of the CHQ side chain results in the production of 7-chloro-4-aminoquinoline (55-56).
The differences can be interpreted as an increase in dealkylation
reactions relative to dehydrogenation and cyclization during pyrolysis of BKT II.