Decompensation

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Related to Decompensated: decompensated shock, decompensated heart failure

decompensation

[dē‚käm·pən′sā·shən]
(psychology)
The deterioration of existing defense mechanisms, leading to an exacerbation of pathologic behavior.

Decompensation

 

disturbance of the activity of an organ, a system of organs, or the entire organism, as a result of exhaustion or disruption of its adaptive mechanisms.

Harmful influences that cause significant changes in the organism disturb the constant equilibrium between the organism and the external environment. After some time, the organism adapts itself to the new conditions of existence (for example, the heart muscle hypertrophies when there are heart defects) and equilibrium is restored—that is, compensation occurs. When there is compensation, the organ (or system) works under an increased load, as a result of which it succumbs more readily to harmful influences.

References in periodicals archive ?
Viral hepatitis is a frequent cause of decompensated cirrhosis, which starts as compensated cirrhosis in which there are no symptoms of the scarring of the liver (cirrhosis).
When liver function worsens and presents with symptoms such as jaundice, malaise, ascites, edema, hepatic encephalopathy, it is called decompensated cirrhosis.
Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE).
A 49-year-old man was admitted to the intensive care unit due to decompensated RV failure.
A high-sodium diot is associated with acute decompensated heart failure in ambulatory heart failure patients: a prospective follow-up study.
Approval was based on data from an ongoing study that randomized patients with chronic hepatitis B and decompensated liver disease to treatment with entecavir, at a dose of 1 mg once daily, or the nucleotide analogue adefovir (10 mg once daily), according to a statement issued by Bristol-Myers Squibb (BMS).
SAN DIEGO -- Plasma levels of serotonin were significantly elevated in patients with decompensated systolic heart failure, compared with patients in the compensated state and with normal controls, according to a single-center study.
a clinical stage pharmaceutical company developing therapeutic agents for the treatment of acute decompensated heart failure (ADHF) and other cardiovascular diseases, announced the presentation of a comprehensive review of the pharmacological effects of nitroxyl (HNO) in the treatment of ADHF.
The adjudicator confirmed the diagnosis of decompensated HF when it was a primary discharge diagnosis, when other causes of dyspnea were absent, and when the treatment plan was consistent with decompensated HF.
The drug is approved to treat patients with acutely decompensated congestive heart failure who experience shortness of breath.
Director, Advanced Heart Failure Treatment Program, University of California San Diego Medical Center, and National Principal Investigator for the MOMENTUM Trial, presented, "Efficacy and Safety of Continuous Aortic Flow Augmentation in Patients Hospitalized with Acute Decompensated Heart Failure: Results of the MOMENTUM Trial.