Dehydrogenases


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Dehydrogenases

 

enzymes that catalyze the removal of hydrogen from organic compounds. The coenzymes of dehydrogenases are usually dinucleotides: nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), which accept hydrogen from the oxidizable substance. Dehydrogenases bring about the first stage of biological oxidation and play a large part in the Krebs cycle, glycolysis, and the pentose phosphate cycle. In the organism the NADP, reduced through the action of certain dehydrogenases, is used to synthesize fatty acids. Some dehydrogenases, unconnected with coenzymes, catalyze the direct oxidation of substances by oxygen. Many dehydrogenases contain metals (zinc or manganese) that are part of their active centers.

G. Z. SOLOV’EVA

References in periodicals archive ?
The analyzed proteins include the complex I or NADH dehydrogenase subunits, the A and B subunits of complex II or succinate dehydrogenase, and various subunits of complex III or cytochrome bcl.
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Thus, systems and methods are provided for the recombinant expression of secoisolariciresinol dehydrogenases that may be used to facilitate the production, isolation and purification of significant quantities of recombinant secoisolariciresinol dehydrogenase for subsequent use, to obtain expression or enhanced expression of secoisolariciresinol dehydrogenase in plants in order to enhance, or otherwise alter, lignan biosynthesis, or may be employed for the regulation or expression of secoisolariciresinol dehydrogenase.