CCR5

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CCR5

(medicine)
Belonging to the seven-transmembrane chemokine receptor family, the major cofactor for primary macrophage-tropic human immunodeficiency virus-1 strains.
References in periodicals archive ?
Researchers at the University of California in San Francisco have created modified white cells with HIV resistance by editing genomes of stem cells which replicates the CCR5 delta 32 mutation found in small number of people in Europe.
The platform is located at West Delta 32 Block in the Gulf of Mexico, 17 miles south east of Grand Isle, LA.
About one in 100 Caucasian people, or one percent of the population, have the mutation, known as Delta 32, inherited from both parents which prevents the protein CCR5 from appearing on the cell surface.
In a meta-analysis involving 619 WNV-seropositive individuals, investigators at the National Institute of Allergy and Infectious Diseases demonstrated that homozygotes for the CCR5 delta 32 mutation had a fourfold increased risk of symptomatic disease (J.
CCR5 is important in guiding trafficking of inflammatory lymphocytes into the CNS, where they can help clear the WNV Studies conducted in excellent mouse models of WNV infection clearly demonstrate that in the presence of the delta 32 mutation, far fewer of these lymphocytes are present in brain tissue, reflecting inhibition of the cell-mediated host immune response to the viral pathogen, the neurologist explained.
Huetter revealed that some people carry a genetic mutation called Delta 32 that apparently makes them resistant to HIV infection.
The CC chemokine receptor 5 (CCR5) delta 32 variant results in a non-functional form of the chemokine receptor, which is incapable of binding beta chemokines (RANTES, MIP-1alpha, MIP-1beta).
Indeed, Crohn's participation in almost a decade of research into his genetic makeup--which may help others who do not have the Delta 32 mutation to battle HIV--has given him a profound sense of meaning.
Finnish medical technology company Instrumentarium said today (3 October) that its subsidiary Instrumentarium Imaging had received clearance from the the US Food and Drug Administration (FDA) to market the Delta 32 and Delta 32 TACT diagnostic digital breast imaging systems in the USA.
Scientists found families of survivors from Eyam, in the Peak District, have a special gene, Delta 32.