avoided the drawbacks of conventional dendrites by avoiding a complex architecturally pure internal dendrimer
structure, but still providing a large number of judiciously placed surface functional groups.
General procedure for the synthesis of amino-terminated (full-generation) PAMAM dendrimers
Drug molecules can be hidden within the core of the dendrimer
or attached to its various branches depending on the sensibilities of the patient.
If you can kill cancer cells without affecting normal cells," says Hongjie Dai, a chemist at Stanford University, "that is the Holy Grail," Among the cast of nanoparticle characters in this work are dendrimers
, carbon nanotubes, and liposomes.
VivaGel(TM) is the first example of a product to come from Starpharma's dendrimer
-based discovery pipeline, which also includes specific programs in the fields of ADME Engineering(TM) (using dendrimers
to control where and when drugs go when introduced to the body), Polyvalency (using the fact that dendrimers
can activate multiple receptors simultaneously) and Targeted Diagnostics (using dendrimers
as a scaffold to which both location-signaling and targeting groups are added to allow location of specific cell type, such as cancer cells).
Under the terms of this agreement, DNT will supply EMD Biosciences with Priofect transfection reagents based on Priostar proprietary dendrimers
for the DNA and siRNA transfection research markets.
as multipurpose nanodevices for oncology drug delivery and diagnostic imaging.
Kleiman's work focuses on molecules known as dendrimers
whose many branching units make them good energy absorbers.
He and his team demonstrated the feasibility of this concept using polyamidoamine dendrimers
and showed it was possible to reproducibly achieve highly specific and sensitive assays for important analytes such as creatine kinase MB subunit, thyroxine, and human thyroid-stimulating hormone.
The highly branched polymers are either dendrimers
3]-MMT nanocomposites, it was expected that polar--polar interactions would predominate in the formation of nanocomposites; however, some repulsion forces, to some extent, were expected between the polar ends whether on the clay surface or that of the dendrimers
A collaborative research study demonstrated that steroids attached to dendrimers
targeted the cells associated with neuroinflammation leaving the rest of the eye unaffected and preserving vision.