Key players in this approach are dendritic cells
, which help control the body's immune response.
Hypothesizing that dendritic cells
might be sensitive targets, the researchers cultured bone marrow-derived dendritic cells
from mice and assayed how both mature and immature cells responded to activation following treatment with thimerosal.
Psoriasis is widely known as a T cell-mediated disease, but animal and clinical studies (most of which have been published since 2003) suggest dendritic cells
also play a role by activating the T cells.
Follicular dendritic cells
in the alternative antigen transport pathway: microenvironment, cellular events, age and retrovirus related alterations.
Cancer Vac is developing immunotherapies based on effective Dendritic Cell
The enigmatic; plasmacytoid T cells develop into dendritic cells
with interleukin (IL)-3 and CD40-ligand.
Langerhan's cells, the dendritic cell
family found in the skin, are stimulated by inflammation signals and migrate to lymph nodes and activate the immune system.
Those T cells are then injected into the patient from whom the dendritic cells
are so named because they have long spindles that give them a star-like appearance.
Follicular dendritic cell
sarcomas generally demonstrate the immunophenotype of nonneoplastic follicular dendritic cells
and are usually positive for dendritic cell
markers CD21 (C3b complement receptor), CD23, and/or CD35 (C3d complement receptor), exhibiting cell membrane staining, although cytoplasmic staining can also be seen.
The Rockefeller University patents licensed by NeoStem are titled: "Methods for use of Apoptotic Cells to Deliver Antigen to Dendritic Cells
for Induction or Tolerization of T Cells," (inventors: Matthew Albert, Nina Bhardwaj, Ralph M.
M2 PHARMA-September 11, 2014-NeoStem licenses exclusive dendritic cells
patent from The Rockefeller University