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Dephosphorylation

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Dephosphorylation 

the splitting-off of a phosphoric acid group from a molecule of a compound containing phosphorus. Some unstable organic phosphorus compounds can undergo spontaneous dephosphorylation, but in living organisms dephosphorylation proceeds primarily with the participation of enzymes. Dephosphorylation brought about by kinases (creatine kinase, glucokinase, and so on) leads to the transfer of the phosphoric acid group to other compounds. Dephosphorylation that is catalyzed by phosphorylases (phosphoamidases) results in the formation of free phosphoric acid. The differentiation among the various types of fermentative dephosphorylation is to some extent arbitrary.



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It is now clear that the major enzyme responsible for the phosphorylation of 5¶-hydroxyl termini and dephosphorylation of 3¶-phosphate termini in human cells is polynucleotide kinase/phosphatase (hPNKP; refs.
When broken, a process called dephosphorylation the molecules of these neurotoxins unravel.
The modification will also alter the functions of a protein in both ways, adding functions or removing functions, for instance, phosphorylation and dephosphorylation, carboxylation and decarboxylation.
 
 
 
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