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An inflammatory reaction of unknown cause involving degenerative changes of skin and muscle.



a systemic disease chiefly involving the skin, muscles, and nerves.

Dermatomyositis was first described by the German physician E. Wagner and (independently) by the German physician H. Unverricht in 1887 and called acute progressive poliomyositis. In 1891, Unverricht suggested the name “dermatomyositis.” The disease has been little studied, and there is no consensus regarding its origin and development. Dermatomyositis may occur in acute or chronic form; in the latter there are intervals of varying duration (remissions) between exacerbations. The manifestations are extremely variable. The commonest are muscular pains, tension in some muscle groups (especially on movement), reddening of certain parts of the skin (most often on the face near the eyes, cheeks , and nose), peeling, and dilatation of blood vessels in the skin (telangiectasia). Hormonal preparations, antibiotics, antimalarial agents, antihistamines and desensitizing preparations, and vitamins are used in treatment. Dermatomyositis patients should be kept under clinical observation.


References in periodicals archive ?
Conclusion: Dysphagia can be the presenting symptom of both dermatomyositis and esophageal cancer.
High incidence of malignancies in patients with dermatomyositis and polymyositis: An 11-year analysis.
Dermatomyositis as paraneoplastic syndrome of peritoneal and ovarian relapse after long-term complete remission in patient with metastatic bilateral breast cancer.
Two patients with polymyositis or dermatomyositis complicated with massive pleural effusion.
To our knowledge, enteroviral infection has not previously been associated with rituximab use in patients who also had hepatitis, dermatomyositis, and edema, as in the cases we report and those associated with XLA (5).
He added: "Although we have not shown a direct cause and effect link between UV exposure and this particular autoimmune disease, this study confirms the association between UV levels and the frequency of dermatomyositis that we found in a previous investigation.
The pulmonary disease was present in 10 of 35 patients with clinically amyopathic dermatomyositis and in 6 of 36 subjects with the classic form of dermatomyositis featuring muscle involvement, rates that were not significantly different (Arch.
First she developed auto-immune disease dermatomyositis - which sometimes indicates cancer is present - but the condition was only diagnosed after her perseverance.
Inflammatory myopathies have been associated with malignancy but are most frequently seen with dermatomyositis (DM) and polymyositis (PM).
Recognition of "mechanic's hands," periungual erythema, abnormal capillary microscopy, and inflammatory arthritis led to new diagnoses including antisynthetase syndrome, systemic sclerosis, rheumatoid arthritis-associated interstitial lung disease, mixed connective tissue disease, dermatomyositis.
The chapter on autoimmune disease and serology was not included in the current edition, and related topics such as anti-neutrophil cytoplasmic antibody, anti-nuclear antibody, dermatomyositis, Raynaud disease, and mixed connective tissue disease were not identified in the index.