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An inflammatory reaction of unknown cause involving degenerative changes of skin and muscle.



a systemic disease chiefly involving the skin, muscles, and nerves.

Dermatomyositis was first described by the German physician E. Wagner and (independently) by the German physician H. Unverricht in 1887 and called acute progressive poliomyositis. In 1891, Unverricht suggested the name “dermatomyositis.” The disease has been little studied, and there is no consensus regarding its origin and development. Dermatomyositis may occur in acute or chronic form; in the latter there are intervals of varying duration (remissions) between exacerbations. The manifestations are extremely variable. The commonest are muscular pains, tension in some muscle groups (especially on movement), reddening of certain parts of the skin (most often on the face near the eyes, cheeks , and nose), peeling, and dilatation of blood vessels in the skin (telangiectasia). Hormonal preparations, antibiotics, antimalarial agents, antihistamines and desensitizing preparations, and vitamins are used in treatment. Dermatomyositis patients should be kept under clinical observation.


References in periodicals archive ?
A diagnosis of dermatomyositis sine myositis was finally made.
Patients with anti-MDA5-positive dermatomyositis express nitric oxide synthase 2 (NOS2) in muscle fibers which can downregulate immune responses and associate with muscle regeneration.
Pilot study of interleukin-27 in pathogenesis of dermatomyositis and polymyositis: associated with interstitial lung diseases.
Serum level of interleukin 21 in patients with dermatomyositis and polymyositis
Clinically, amyopathic dermatomyositis (CADM) is a variant phenotype of dermatomyositis defined by characteristic skin manifestations such as a heliotrope rash and Gottron's papules (1), but little or no evidence of myopathy_ENREF_2.
The report provides a snapshot of the global therapeutic landscape of Dermatomyositis
Severe calcinosis cutis with cutaneous ulceration in juvenile dermatomyositis.
We recently encountered a dermatomyositis patient with metastatic seminoma, which is extremely rare as an accompanying tumor.
Muscle histopathologic findings from a biopsy of the quadriceps showed features of an inflammatory myopathy (interstitial edema, perivascular lymphocytic cuffing, and degenerating fibers) consistent with the features of early dermatomyositis.
Dermatomyositis (DM) is a rare autoimmune process with not yet fully understood aetiology.
Eloise, 13, has been diagnosed with juvenile dermatomyositis, an autoimmune dysfunction that has left her muscles weak, meaning she is often reliant on a wheelchair or confined to bed.