Contrary to popular scientific thinking the researchers revealed a revolutionary finding -- that the desmosomes
achieve their strength through flexibility rather than rigidity.
are also thought to be involved in helping to suppress cancer.
consist of 2 desmosomal-specific cadherin family members desmogleins (DSGs) and desmocollins (DSCs).
This protein can be then incorporated into desmosomes
, or used for the formation of new desmosomes
For epithelioid mesotheliomas these include very long, thin apical microvilli that do not have a glycocalyx, as opposed to the generally shorter microvilli of adenocarcinomas that usually do have a glycocalyx; perinuclear tonofilament bundles; the presence of basal lamina; and long desmosomes
We know that people who have defects in their desmosomes
have problems with their epidermis and get extremely unpleasant skin diseases.
But in the Transmission Electron Micrographs, their cellular ultrastructure was visible and the entire length of cells lay stretched along the length of the fibers establishing tight junctions with neighbouring cells or with close cell-cell communication through the desmosomes
(Fig 5a, b).
signaling), cell matrix adhesions in three dimensions, cell-cell junctions, signaling to and through the endothelial adherens junction, gap junctions (connexin functions), tight junctions in simple and stratified epithelium, desmosomes
in development and disease, cadherin trafficking and junction dynamics, and cross-talk in cell-cell and cell-matrix adhesions.
Immunoelectron microscopy has localized both pemphigus vulgaris (desmoglein 3) and pemphigus foliaceus (desmoglein 1) antigens to the desmosomes
, the most prominent cell-cell adhesion junctions in stratified squamous epithelia (12, 13).
The finding of epithelial elements, mature desmosomes
, and tonofilaments in the original neoplasm secured the diagnosis of spindle-cell squamous carcinoma.
Pemphigus vulgaris is an autoimmune skin disease characterized by acantholytic skin lesions with autoantibodies directed against desmoglen, plakoglobins, and cadherin polypeptides of desmosomes
and other cell-cell adhesion molecules.
are adhesive structures that are intimately involved in maintaining the structure, function and integrity of the skin and other epithelial tissues.