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Deoxycorticosterone
(redirected from Desoxycorticosterone)

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deoxycorticosterone [dē¦äk·sē‚kȯrd·ə′kä·stə‚rōn]
(biochemistry)
C21H30O3A steroid hormone secreted in small amounts by the adrenal cortex.
Deoxycorticosterone 

(also cortexone), an intermediate product in the biosynthesis of hormones of the adrenal cortex. Formed primarily from progesterone, it is a mineralocorticoid, that is, an active regulator of mineral metabolism, and in this connection the most stable preparation of deoxycorticosterone is deoxycorticosterone acetate, which is used in medicine.
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In a basic physiologic study that looked at isolated aortas from both normotensive and desoxycorticosterone acetate (DOCA)-salt hypertensive rats, it was found that "changes in extracellular magnesium concentration differentially alter endothelin-1-induced contraction in aortae from normotensive and hypertensive rats, possibly by interfering with calcium utilization during contraction.
Magnesium: Its proven and potential clinical significance by Carter, Cathleen / Southern Medical Journal
Clinical investigation on the use of CoQ for treatment of hypertension began when Igarashi et al (19) reported that CoQ reduced elevated blood pressure in unilaterally nephrectomized rats treated with desoxycorticosterone and saline.
Randomized, Double-Blind, Placebo-Controlled Trial of Coenzyme Q10 in ... by Olson, Richard D. / Southern Medical Journal
 
 
 
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