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Dextran

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dextran [′dek ‚stran]
(biochemistry)
Any of the several polysaccharides, (C5H10O5)n, that yield glucose units on hydrolysis.

Dextran 

(C6H10O5)n, a polysaccharide of bacterial origin, a polymer of glucose. The molecular weight can be as high as 10,000,000. In the linear part of the dextran molecule the glucose residues are joined by bonds between the first and sixth carbon atoms; branching is due to bonds between the first and fourth, first and third, and first and second atoms. Dextran is obtained by growing microorganisms of the genus Leuconostoc in an artificial culture medium. Dextran, in the form of a partially hydrolyzed solution with not less than 90 percent 1.6 linkages and a molecular weight of about 60,000 is used clinically as a blood plasma substitute. The preparation provides for a normal osmotic pressure corresponding to that of blood. Modified dextran, so-called Sephadex, is used in chromatography.



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The first reagent contains a-cyclodextrin and dextran sulfate to stabilize LDL-C, VLDL, and chylomicrons.
In addition, essential oil extracts from the three Eucalyptus species produced antiinflammatory effects, as demonstrated by inhibition of rat paw edema induced by carrageenan and dextran, neutrophil migration into rat peritoneal cavities induced by carrageenan, and vascular permeability induced by carrageenan and histamine.
However, it is unable to ascertain the site of the leak; to do so, iodine 131 polyvinylpyrrolidine, iodine 125 polyvinylpyrrolidone, chromium 51-labelled albumin, chromium 51 chromic chloride, iodine 125 albumin, indium 111 chloride, indium-transferring Tc-99m diethylenetriaminepenta-acetic acid HSA, Tc-99m dextran, and Tc-99m human immunoglobulin have been used with success.
 
 
 
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