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congenital anomaly of the metabolic processes of an organism in which the functions and metabolism of the organism enter a state of prolonged unstable equilibrium that is expressed in unique pathological reactions and illnesses.

The inherited predisposition is actually the result of a unique accumulation through preceding generations of characteristics that occur in the organism both owing to the effect of unfavorable environmental conditions and in association with congenital anomalies of the organism’s internal environment. The mechanism of development of diathesis is closely linked with the autonomic nervous system and internal secretion. When conditions of the external environment grow worse (disruption of diet or schedule, illness of the organism) and with functional impairment of the central or autonomic nervous system, the neural regulatory mechanisms cannot ensure proper functioning by organs and proper metabolism. As a result the organism’s ability to adapt to the environment is reduced, its reactivity changes, and a predisposition to certain diseases arises. With diathesis even physiological stimuli and ordinary living conditions can cause pathological reactions and lead to illness. The predisposition to illnesses can be lessened and sometimes even eliminated.

Diathesis usually manifests itself during childhood. Sometimes constitutional anomalies can only be identified by careful investigation of the functional state of the central and autonomic nervous systems and investigation of morphological, functional, and biochemical changes in a number of systems and in the metabolism of the organism as a whole. There are different forms of diathesis. The most commonly encountered are exudative-catarrhal diathesis, lymphatic-plastic diathesis, and neural-arthritic diathesis. The manifestations of neural-arthritic diathesis change with age; in the nursing stage there is a causeless disposition to impairments of digestion and diet, increased nervous excitability, and other characteristics, while later abnormal emaciation or obesity occurs and there is vomiting during mental excitation, cardiospasm, and so on. There is no clear distinction between different forms of diathesis, and therefore they are sometimes considered variations of one diathesis that manifests itself differently depending on age. The hemorrhagic diatheses constitute a special group.

References in periodicals archive ?
She developed bleeding diathesis and petechiae all over her body.
Some authors even suggest to resign from using conventional metal alloys in patients with known allergic diathesis since their corrosion products showed cytotoxic and proinflammatory effects.
Mild form of leptospirosis has been defined at mild to moderate intoxication, anicteric or mild icterus, without hemorrhagic diathesis, without involvement of respiratory, cardiac and central nervous system (CNS), with mild renal dysfunction without acute renal failure (ARF).
Bleeding diathesis and paradoxical thrombosis can occur.
A 63-year-old Caucasian female with no known history of trauma, anticoagulation or bleeding diathesis was presented to the emergency department with sudden-onset, sharp abdominal and right flank pain.
Patient factors associated with an increased risk of vascular complications include hypertension, female sex, bleeding diathesis, peripheral arterial disease (PAD), age and obesity (2).
In a patient with a bleeding diathesis, a detailed personal and family bleeding history should he obtained before beginning a laboratory evaluation of platelet function.
Gideon Goldenberg, "Actants and Diathesis, Directions of Transitivity &c.
Many TCs are, in this sense, illustrative examples of diathesis, "[t]he grammatical device used to present the same situation from different points of view (i.
4] Classically, there have been two absolute con-traindications for SWL: pregnancy and bleeding diathesis.
Occasional keratinisation was seen in the malignant cells and tumor diathesis was present in the background.