Diazotization


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diazotization

[dī‚az·ət·ə′zā·shən]
(organic chemistry)
Reaction between a primary aromatic amine and nitrous acid to give a diazo compound. Also known as diazo process.

Diazotization

 

the reaction of preparing diazo compounds by the action of nitrous acid (or its derivatives) on primary amines in the presence of inorganic acids (HCl, H2SO4, or HNO3) at 0°-5°C. The diazotization of aromatic amines to yield diazonium salts is the most common—for example, aniline is diazotized to phenyldiazonium chloride:

In organic synthesis, diazotization is used extensively to make various aromatic compounds through the diazonium salt, as well as to synthesize dyes, particularly azo dyes.

References in periodicals archive ?
These compounds can be accessed through biarylation of nitroaryls followed by diazotization.
1-1 Main products with diazotization technique route in China, 2011
Fischhach [32] determined sulpha-drugs in aqueous solution by diazotization with sodium nitrite in presence of acid, using p-dimethylaminobenzaldehyde as internal indicator.
The absorbance of the chromophore formed during diazotization of the nitrite with sulphanilamide and subsequent coupling with N-1-naphthylethylene diamine dihydrochloride was measured at 546 nm and percentage scavenging activity was measured with reference to standard.
Methods: Partially purified Amaranthus spinosus leaf oxalate oxidase was immobilized through diazotization onto arylamine glass beads affixed on the surface of a plastic strip by a non reactive fixative and employed for oxalate determination in urine and serum samples collected from healthy individuals and urinary stone formers.
3]-N concentrations (by diazotization following hydrazine reduction) were measured on a Technicon AutoAnalyzer II system (Blakemore et al.
Diazotization of the amine produces a diazonium intermediate that is not isolated but is reduced with tin chloride to the corresponding hydrazine.
The absorbance of chromophore formed during diazotization of nitrite with sulfanilamide and subsequent coupling with naphthalene diamine was read at 546 nm.
We isolated the dimer 5 and the trimer 6 by LAH-mediated diazotization of the corresponding biphenyls.
4,4,4- trichloro-3-oxo-2-(phenyl-hydrazono)-butyric acid ethyl ester 2 was prepared by diazotization of required primary amine is diazotized with sodium nitrile and HCl mixture at 0-5 and it is coupled with ethyl 4,4,4-trichloro-3-oxobutanoate and afforded phenyl diazonium aceto acetic ester