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For example, the inhibition of CES1 and CES2 by triclosan was totally unexpected, as was the inhibition of the RyRs by chloranil and dichlone.
Although we identified compounds that were previously shown to inhibit a particular enzyme class or receptor, we surprisingly discovered that triclosan, a microbiocide present in personal care products, inhibits carboxylesterases and that dichlone, a fungicide, strongly inhibits the ryanodine receptors.
Pesticide Cases (n = 110) Controls (n = 358) [n (%)] [n (%)] Oxidative stressors Paraquat 23 (24) 49 (14) Permethrin 16 (16) 41 (12) Carbon disulfide 2 (2) 3 (1) Chloranil 1 (1) 3 (1) Cyhalothrin 1 (1) 1 (0) Dichlone 3 (3) 8 (2) Mercury compounds 2 (2) 5 (1) Pybuthrin 0 (0) 6 (2) Any oxidative stressor 35 (40) 93 (28) Mitochondrial complex I inhibitors Benomyl 7 (7) 15 (4) Carbendazim 1 (1) 2 (1) Cyhalothrin 1 (1) 1 (0) Permethrin 16 (16) 41 (12) Pyridaben 0 (0) 1 (0) Rotenone 19 (19) 32 (9) Thiabendazole 3 (3) 12 (3) Any complex I inhibitor 36 (38) 92 (27) Pesticide OR (95% CI) p-Value Oxidative stressors Paraquat 2.