dichloroacetic acid

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dichloroacetic acid

[dī¦klȯr·ō·ə¦sēd·ik ′as·əd]
(organic chemistry)
CHCl2COOH A strong liquid acid, formed by chlorinating acetic acid; used in organic synthesis.
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References in periodicals archive ?
Dutta, "A potent tumoricidal co-drug 'Bet-CA'--an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cells," Scientific Reports, vol.
2014) Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and miltiorgan failure in severe influenza.
noted a reduction in Lac and Ala after treating ECM infection with dichloroacetate (DCA).
Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate.
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage gated potassium channels.
The new compound called, mitaplatin, combines cisplatin with another compound, dichloroacetate (DCA), that alters the properties of mitochondria selectively in cancer cells.
2000) Effects of pdh activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.
The label might refer to the negatively charged dichloroacetate anion related to dichloroacetic acid or the acid itself.
Reviews of case studies reveal that IV and oral preparations of dichloroacetate used during acute stroke and prophylaxis of stroke have a decreased number and severity of strokes in patients with MELAS syndrome.
The purpose of this clinical trial is to determine whether the drug NTBC(Nitisione, Orfadinin TM) reduces or prevents the undesirable side effects (toxicity), of the investigational drug, dichloroacetate (DCA), in patients with Congenital Lactic Acidosis.

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