dichloroacetic acid

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dichloroacetic acid

[dī¦klȯr·ō·ə¦sēd·ik ′as·əd]
(organic chemistry)
CHCl2COOH A strong liquid acid, formed by chlorinating acetic acid; used in organic synthesis.
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References in periodicals archive ?
Stacpoole and his colleagues have begun limited human trials of dichloroacetate.
Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate.
Moreover, increased flux through the Krebs cycle, via dichloroacetate action, stimulated the levels of PPSS I mRNA.
Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria.
The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.
It is now well accepted that hepatocarcinogenicity is caused by a metabolite, trichloroacetate (TCA), although a contribution by its dichloroacetate (DCA) analog cannot be discounted at this time (Bull 2000; Bull et al.
Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice.
Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes.
Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.
Mode of action for liver tumor induction by trichloroethylene and its metabolites trichloroacetate and dichloroacetate.
Role of dichloroacetate in the treatment of genetic mitochondrial diseases.

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