Dutta, "A potent tumoricidal co-drug 'Bet-CA'--an ester derivative of betulinic acid and dichloroacetate
selectively and synergistically kills cancer cells," Scientific Reports, vol.
2014) Diisopropylamine dichloroacetate
, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and miltiorgan failure in severe influenza.
noted a reduction in Lac and Ala after treating ECM infection with dichloroacetate
Liver tumor induction in B6C3F1 mice by dichloroacetate
, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage gated potassium channels.
The new compound called, mitaplatin, combines cisplatin with another compound, dichloroacetate
(DCA), that alters the properties of mitochondria selectively in cancer cells.
2000) Effects of pdh activation by dichloroacetate
in human skeletal muscle during exercise in hypoxia.
Buli RJ, Sanchez IM, Nelson MA, Larson JL, Lansing AL (1990) Liver tumour induction in B6C3F1 mice by dichloroacetate
Therapeutic potential of dichloroacetate
for pyruvate dehydrogenase complex deficiency.
The label might refer to the negatively charged dichloroacetate
anion related to dichloroacetic acid or the acid itself.
Reviews of case studies reveal that IV and oral preparations of dichloroacetate
used during acute stroke and prophylaxis of stroke have a decreased number and severity of strokes in patients with MELAS syndrome.
The purpose of this clinical trial is to determine whether the drug NTBC(Nitisione, Orfadinin TM) reduces or prevents the undesirable side effects (toxicity), of the investigational drug, dichloroacetate
(DCA), in patients with Congenital Lactic Acidosis.