DIELS-ALDER REACTIONS ON SILICA AND IN SOLUTION, Khaleh Thomas *, Joey Jarrard, Michael Tang, and John T.
The importance of this achievement has been ranked with that of the Diels-Alder reaction
(diene synthesis) for which the 1950 Nobel Prize for Chemistry was awarded (6).
Asymmetric Catalysis of Diels-Alder Reaction
(Haifeng Du and Kuiling Ding)
Wide-ranging collaborative projects with experimentalists are addressing problems related to facial-selectivity in the Diels-Alder reaction
, the design of conducting organic polymers, and the prediction of transition-state structures from experimental kinetic isotope effects.
Specific reactions, such as the inverse electron demand Diels-Alder reaction
and directed lithation (both reviewed in volume 1), continue to find use, as do applications of free radical reactions, in heterocyclic syntheses.
In the area of methodology, the emphasis is on photocycloaddition-fragmentation reactions, new applications of the Diels-Alder reaction
, development of synthetically useful phosphorus-containing reagents, chemical reactivity of Ce(III) enolates, and synthetic application of thiol esters.
David Baker at University of Washington in Seattle (outgoing host) has made a breakthrough in the development of Computational Enzyme Design strategies to create new enzymes able to catalyze retro-aldol, Kemp elimination and Diels-Alder reactions
He has identified novel reactions promoted by N-heterocyclic organocatalysts including stereoselective redox esterifications, lactam and lactone synthesis via catalytically generated homoenolates, and highly enantioselective inverse electron demand Diels-Alder reactions
to attach 1,2-dihydro-4-chloroformylbenzocyclobutene end-capped polymers (12) onto EPDM have been performed in a Brabender batch mixer at high temperatures (250-280 [degrees] C).
17 Two-Group C-C Disconnections I: Diels-Alder Reactions
Newer methods, such as palladium catalysed reactions and aza- and reverse electron demand Diels-Alder reactions
, are well documented.
16 Unprecedented Electro-optic Properties in Polymers and Dendrimers Enabled by Click Chemistry Based on the Diels-Alder Reactions