Diketopiperazines


Also found in: Medical.

Diketopiperazines

 

six-membered heterocyclic compounds that are piperazine derivatives. They are cyclic anhydrides of ±-amino acids:

Diketopiperazines are colorless crystals. Neutral compounds, they are readily soluble in hot water, but only slightly soluble in cold water. The hydrolysis of diketopiperazines yields dipeptides, then amino acids. Sodium in alcohol reduces diketopiperazines to piperazines.

Diketopiperazines can be made by cyclizing a-amino acids or their esters; they can also be isolated from the hydrolisates of proteins.

References in periodicals archive ?
Citromycetins and bilains A-C: new aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial Penicillium spp.
Received notification of the granting of a Canadian patent with broad claims directed to compositions containing either DA-DKP, a cyclic dipeptide diketopiperazine, which is the active ingredient of Ampion[TM], but also extends to many other diketopiperazines.
NASDAQ: AMPE - News) ("Ampio" or the "Company"), a company that discovers and develops new uses for previously approved drugs and new molecular entities ("NMEs"), today announced notification of the granting of a Canadian patent with broad claims directed to: "METHOD OF USING DIKETOPIPERAZINES AND COMPOSITION CONTAINING THEM".