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The following undergraduate laboratory procedure for the synthesis of diphenylmethanol using the Grignard methodology according to Scheme 1 is given as an illustrative example where the present analysis is employed.
Under conditions of using excess reagents (benzaldehyde is the limiting reagent) and committing all materials other than target product to waste, the overall RME for production of diphenylmethanol is 1.
Minor products include diphenylmethanol and 1,1-diphenylethanal.