diphtheria (redirected from Diphtheira)

diphtheria (dĭfthēr`ēə), acute contagious disease caused by Corynebacterium diphtheriae (Klebs-Loffler bacillus) bacteria that have been infected by a bacteriophage. It begins as a soreness of the throat with fever. The bacteria lodge in the mucous membranes of the throat, producing virulent toxins that destroy the tissue. The resultant formation of a tough gray membrane is one of the most dangerous aspects of diphtheria, since it can spread to the larynx and cause suffocation. Deaths from diphtheria often result from inflammation of the heart. Diphtheria usually occurs in children of preschool age. Treatment with antitoxin is begun as early as possible. Penicillin or erythromycin is also given, particularly to guard against complicating factors such as pneumonia or streptococcal infection. Diphtheria was once a common and dreaded disease with a high mortality rate; it is now rare in countries where infants are vaccinated (see vaccination). Underimmunization, however, can lead to epidemics such as the one in Russia during 1994–95.

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diphtheria

Acute infectious bacterial disease caused by Corynebacterium diphtheriae. The bacterium usually enters through the tonsils, nose, or throat and multiplies there, forming a thick membrane that adheres to the tissues and sometimes blocks the trachea, requiring emergency treatment.The bacteria produce a toxin that spreads to cause other symptoms, including fever, chills, sore throat, and lesions in heart muscle and peripheral nerve tissue that may cause death from heart failure and paralysis. Diphtheria is treated with an antitoxin that neutralizes the toxin and produces long-term immunity. Vaccination has greatly reduced its occurrence in Europe and North America.

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diphtheria

an acute contagious disease caused by the bacillus Corynebacterium diphtheriae, producing fever, severe prostration, and difficulty in breathing and swallowing as the result of swelling of the throat and formation of a false membrane

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diphtheria [dif′thir·ē·ə]

(medicine)

A communicable bacterial disease of humans caused by the growth ofCorynebacterium diphtheriaeon any mucous membrane, especially of the throat.

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Diphtheria

An acute infectious disease of humans caused by Corynebacterium diphtheriae. Classically, the disease is characterized by low-grade fever, sore throat, and a pseudomembrane covering the tonsils and pharynx. Complications such as inflammation of the heart, paralysis, and even death may occur due to exotoxins elaborated by toxigenic strains of the bacteria. The upper respiratory tract is the most common portal of entry for C. diphtheriae. It can also invade the skin and, more rarely, the genitalia, eye, or middle ear. The disease has an insidious onset after a usual incubation period of 2–5 days.

The only specific therapy is diphtheria antitoxin, administered in doses proportional to the severity of the disease. Antitoxin is produced by hyperimmunizing horses with diphtheria toxoid and toxin. It is effective only if administered prior to the binding of circulating toxin to target cells. Antibiotics do not alter the course, the incidence of complications, or the outcome of diphtheria, but are used to eliminate the organism from the patient.

Persons with protective antitoxin titers may become infected with diphtheria but do not develop severe disease. Since the 1920s, active immunization with diphtheria toxoid has proved safe and effective in preventing diphtheria in many countries. Diphtheria toxoid is produced by incubating the toxin with formalin. Active immunization requires a primary series of four doses, usually at 2, 4, 6, and 18 months of age, followed by a booster at school entry. See Immunity, Medical bacteriology, Toxin, Vaccination