Pharmacokinetics, pharmacodynamics and clinical effects of the oral direct thrombin inhibitor
ximelagatran in acute treatment of patients with pulmonary embolism and deep vein thrombosis.
If there is concern about dabigatran presence, a thrombin time (TT), which is very sensitive to the presence of direct thrombin inhibitors
, can be performed to avoid the delay in appropriate evaluation.
Heparin-induced thrombocytopenia--therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors
, inhibit formation of platelet factor 4-heparin complexes.
A dose-ranging study of the oral direct thrombin inhibitor
, ximelagatran, and its subcutaneous form, melagatran, compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I.
The direct thrombin inhibitors
currently hold the most promise.
Efficacy and tolerability of the novel, oral direct thrombin inhibitor
, ximelagatran (pINN, formerly H 376/95), compared with standard therapy for the treatment of acute deep vein thrombosis [Abstract OC 2348].
Dabigatran, approved in Canada and Europe, is the first of this class of drugs being developed to provide an opportunity to evaluate other direct thrombin inhibitor
Pharmacokinetic profile of the oral direct thrombin inhibitor
dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement.
Antman disclosed no relationship with Boehringer Ingelheim, but he has relationships with several other drug companies, including a company developing a rival direct thrombin inhibitor
4) A successful alternative to heparin is the direct thrombin inhibitor
(DTI) class, including argatroban, lepirudin, and bivalirudin.
Dabigatran etexilate is an oral direct thrombin inhibitor
, a new oral anticoagulant in advanced development.
Many novel antithrombotic agents will enter phase II or phase III trials for AF in 2006, including the oral direct thrombin inhibitor
dabigatran, the indirect thrombin inhibitor odiparcil, and idraparinux, a once-weekly injectable selective factor Xa inhibitor.